1. Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies
- Author
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Rakesh Ganguly, Lit-Hsin Loo, Kiat Hwa Chan, Weng Kee Leong, Richard D. Webster, Jia-Ying Joey Lee, Zhen Xuan Wong, Zhiyong Lam, Jia Wen Kong, and School of Physical and Mathematical Sciences
- Subjects
Cluster chemistry ,Toxicity ,Metal carbonyl cluster ,Cells ,General Chemical Engineering ,chemistry.chemical_element ,Metal carbonyl ,General Chemistry ,Medicinal chemistry ,Article ,Chemistry ,chemistry.chemical_compound ,chemistry ,Metals ,Cell culture ,Apoptosis ,Carbonyls ,Chemistry [Science] ,Osmium ,skin and connective tissue diseases ,Mode of action ,Cytotoxicity ,QD1-999 ,Boronic acid - Abstract
A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death. Ministry of Education (MOE) Nanyang Technological University Published version This work was supported by Nanyang Technological University and the Ministry of Education (Research grant no. RG121/18).
- Published
- 2021
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