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Stoichiometric Mn0.2Zn0.8Fe2O4 monodisperse nanoparticles were prepared by the so-called polyol method. The variation of magnetization as a function of magnetic field H (up to ±50 kOe) and temperature (5−320 K) were investigated, for zero-field-cooled (ZFC) and field-cooled (FC) conditions on freshly produced powder. The T variation of the low-field (H = 200 Oe) magnetic susceptibility is characteristic of superparamagnets with a blocking temperature below room temperature. The H variation of the low temperature (T = 5 K) magnetization exhibits a hysteresis loop. The coercivity is weak, about 0.2−0.3 kOe, which is typical of soft-ferrimagnetic materials. The 0 K saturation magnetization and the Curie temperature are found to be 98 emu.g−1 and 360 K, respectively. The magnetic properties of the particles are discussed in relation with their chemical composition and their cation distribution in the opportunity of using them as heating mediators for hyperthermia application in cancer therapy. In this aim, th...

Carbon nanotube-based drug delivery holds great promise for cancer therapy. Herein we report the first targeted, in vivo killing of cancer cells using a drug-single wall carbon nanotube (SWNT) bioconjugate, and demonstrate efficacy superior to non-targeted bioconjugates. First line anti-cancer agent cisplatin and epidermal growth factor (EGF) were attached to SWNTs to specifically target squamous cancer, and the non-targeted control was SWNT-cisplatin without EGF. Initialin vitro imaging studies with head and neck squamous carcinoma cells (HNSCC) overexpressing EGF receptors (EGFR) using Qdot luminescence and confocal microscopy showed that SWNT-Qdot-EGF bioconjugates internalized rapidly into the cancer cells. Limited uptake occurred for control cells without EGF, and uptake was blocked by siRNA knockdown of EGFR in cancer cells, revealing the importance of EGFEGFR binding. Three color, two-photon intra-vital video imagingin vivo showed that SWNT-Qdot-EGF injected into live mice was selectively taken up by HNSCC tumors, but SWNT-Qdot controls with no EGF were cleared from the tumor region in