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Start Over Author "Kang, Xi" Publisher american chemical society (acs)
40 results on '"Kang, Xi"'

10. Gram-Scale Preparation of Stable Hydride M@Cu24 (M = Au/Cu) Nanoclusters

Author

Shuxin Wang, Wenjun Du, Along Chen, Manzhou Zhu, Kang Xi, and Shan Jin

Subjects
Materials science, Hydride, Ligand, Electrospray ionization, Doping, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Nanoclusters, Metal, Crystallography, chemistry.chemical_compound, chemistry, visual_art, visual_art.visual_art_medium, Copper hydride, General Materials Science, Physical and Theoretical Chemistry, 0210 nano-technology, Phosphine
Abstract

The instability of phosphine ligated copper hydride nanoclusters (CuH NCs) has largely limited their application in areas such as H2 storage, CO2 reduction, etc. In this work, the stability of CuH NCs was remarkably enhanced by improving their antioxidant capacity through two different approaches: (i) metal doping and (ii) ligand modification. Three NCs, AuCu24H22(PPh3)12, Cu25H22((p-FPh)3P)12, and AuCu24H22((p-FPh)3P)12, were controllably synthesized, and their structures were determined by single-crystal X-ray diffraction. The compositions of these NCs were further confirmed by electrospray ionization mass spectrometry and nuclear magnetic resonance. More importantly, we achieved gram-level production of M@Cu24 (M = Cu/Au) NCs protected by electron-withdrawing ligands (p-FPh)3P, which in turn proved their superior stability; such a large-scale preparation laid the foundation for future explorations of copper-rich NCs. This work hopes to shed light on large-scale generation of ultrastable Cu-based NCs.

Published
2019
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15. Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation

Author

Fang, Yang, primary, Lu, Xueguang, additional, Wang, Dali, additional, Cai, Jiansong, additional, Wang, Yuyan, additional, Chen, Peiru, additional, Ren, Mengqi, additional, Lu, Hao, additional, Union, Jennifer, additional, Zhang, Lei, additional, Sun, Yehui, additional, Jia, Fei, additional, Kang, Xi, additional, Tan, Xuyu, additional, and Zhang, Ke, additional

Published
2021
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34. Allosterically Controllable Maxizyme-Mediated Suppression of Progression of Leukemia in Mice

Author

Tomoko Kuwabara, Shigetaka Asano, Tsuyoshi Tanabe, Kenzaburo Tani, Masaki Warashina, Kazunari Taira, and Kang Xi Xiong

Subjects
Polymers and Plastics, Transplantation, Heterologous, Apoptosis, Bone Marrow Cells, Bioengineering, Mice, SCID, Biology, Biomaterials, Mice, Allosteric Regulation, Leukemic Infiltration, Mice, Inbred NOD, Transduction, Genetic, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Tumor Cells, Cultured, Materials Chemistry, medicine, Animals, Humans, RNA, Catalytic, neoplasms, Bone Marrow Transplantation, Messenger RNA, Ribozyme, Genetic Therapy, medicine.disease, Haematopoiesis, Leukemia, medicine.anatomical_structure, Cell culture, Drug Design, Immunology, biology.protein, Cancer research, Bone marrow, Chronic myelogenous leukemia
Abstract

Chronic myelogenous leukemia (CML) is a hematopoietic malignant disease associated with expression of a chimeric BCR-ABL gene. We recently succeeded in designing a novel allosterically controllable ribozyme, the maxizyme (Tanabe et al. Biomacromolecules 2000, 1, 108-117; Kuwabara et al. Biomacromolecules 2001, 2, 788-799), that not only specifically cleaves BCR-ABL mRNA and induces apoptosis in cultured CML cells but also shows significant inhibition against the growth of an established BV173 cell line in a mouse model (Tanabe et al. Nature 2000, 406, 473-474). As an extension of our studies, we tested the maxizyme against primary CML cells in the same mouse model. The maxizyme under the control of a tRNA(Val) promoter showed significant inhibition against the growth of the primary bone marrow cells from a Japanese patient with CML. Specifically, to examine the applicability of the maxizyme in the treatment of CML, we assessed the antitumor effect of the maxizyme in murine models of CML. Fourteen weeks after the injection of primary CML cells into a NOD-SCID mouse, the bone marrow of the mouse was filled with primary CML cells as a result of diffuse leukemia. In marked contrast, when maxizyme-expressing primary CML cells were injected, the mouse remained disease-free. These results further strengthen our earlier suggestion that the maxizyme technology might provide a useful approach to the treatment of CML.

Published
2001
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36. Droplet Deformation and Structure Formation in Two-Phase Polymer/Polymer/Toluene Mixtures in an Electric Field

Author

Kang Xi and Sonja Krause

Subjects
chemistry.chemical_classification, Materials science, Polymers and Plastics, Field (physics), Organic Chemistry, Polymer, Inorganic Chemistry, chemistry.chemical_compound, Polybutadiene, chemistry, Chemical engineering, Electric field, Phase (matter), Polymer chemistry, Materials Chemistry, Vinyl acetate, Polymer blend, Polystyrene
Abstract

Droplet deformation and the development of the final morphology after solvent evaporation were studied in two-phase ternary polymer/polymer/solvent mixtures in an electric field. The polymer mixtures used included polystyrene (PS) with such other polymers as poly(vinyl acetate) (PVA), poly(methyl methacrylate) (PMMA), or polybutadiene (PB) in toluene as a solvent. In a dc field, the dispersed phases were distorted into ellipsoids with their major axes either parallel (prolate ellipsoids) or perpendicular (oblate ellipsoids) to the field direction, and/or they aligned in the field direction to form pearl chains. Droplets of the dispersed phases sometimes coalesced to form columns either parallel or perpendicular to the electric field direction. Sometimes the droplets or columns broke up into smaller droplets in the dc field. The final morphology usually contained spheres or prolate or oblate ellipsoids either randomly distributed in the matrix or in the form of pearl chains or columns. It was found that th...

Published
1998
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