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Your search keyword '"Landry, Serge"' showing total 12 results
Start Over Author "Landry, Serge" Publisher american chemical society (acs)
12 results on '"Landry, Serge"'

1. Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs

Author

Fader, Lee D., primary, Bailey, Murray, additional, Beaulieu, Eric, additional, Bilodeau, François, additional, Bonneau, Pierre, additional, Bousquet, Yves, additional, Carson, Rebekah J., additional, Chabot, Catherine, additional, Coulombe, René, additional, Duan, Jianmin, additional, Fenwick, Craig, additional, Garneau, Michel, additional, Halmos, Ted, additional, Jakalian, Araz, additional, James, Clint, additional, Kawai, Stephen H., additional, Landry, Serge, additional, LaPlante, Steven R., additional, Mason, Stephen W., additional, Morin, Sebastien, additional, Rioux, Nathalie, additional, Simoneau, Bruno, additional, Surprenant, Simon, additional, Thavonekham, Bounkham, additional, Thibeault, Carl, additional, Trinh, Thao, additional, Tsantrizos, Youla, additional, Tsoung, Jennifer, additional, Yoakim, Christiane, additional, and Wernic, Dominik, additional

Published
2016
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2. The Exocyclic Effect: Protecting Group Strategy to Enhance Stereoselectivity in Hydrogen Transfer Reactions of Acyclic Free Radicals

Author

Anne-Marie Faucher, Grace Jung, Yvan Guindon, Landry Serge, Valérie Caron, and Élyse Bourque

Subjects
Steric effects, State model, chemistry.chemical_compound, chemistry, Stereochemistry, Radical, Organic Chemistry, Hydrogen transfer, Stereoselectivity, Bifunctional, Protecting group, Stereocenter
Abstract

To enhance the diastereoselectivity of the hydrogen transfer reaction of acyclic substrates bearing 1,2- or 1,3-diols, the feasibility of a strategy employing bifunctional protecting groups has been demonstrated. This strategy is based upon the “exocyclic effect” or the significant improvement of anti-selectivity exhibited by the reductions of substrates in which the two substituents (R1 and Y) at the stereogenic center α to the radical center are linked together. A rationale for the excellent facial discrimination of these exocyclic radicals is offered based on an analysis of transition state models, which considers both steric and electronic factors.

Published
1997
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3. Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Author

Fader, Lee D., primary, Malenfant, Eric, additional, Parisien, Mathieu, additional, Carson, Rebekah, additional, Bilodeau, François, additional, Landry, Serge, additional, Pesant, Marc, additional, Brochu, Christian, additional, Morin, Sébastien, additional, Chabot, Catherine, additional, Halmos, Ted, additional, Bousquet, Yves, additional, Bailey, Murray D., additional, Kawai, Stephen H., additional, Coulombe, René, additional, LaPlante, Steven, additional, Jakalian, Araz, additional, Bhardwaj, Punit K., additional, Wernic, Dominik, additional, Schroeder, Patricia, additional, Amad, Ma’an, additional, Edwards, Paul, additional, Garneau, Michel, additional, Duan, Jianmin, additional, Cordingley, Michael, additional, Bethell, Richard, additional, Mason, Stephen W., additional, Bös, Michael, additional, Bonneau, Pierre, additional, Poupart, Marc-André, additional, Faucher, Anne-Marie, additional, Simoneau, Bruno, additional, Fenwick, Craig, additional, Yoakim, Christiane, additional, and Tsantrizos, Youla, additional

Published
2014
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4. Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency

Author

Hucke, Oliver, primary, Coulombe, René, additional, Bonneau, Pierre, additional, Bertrand-Laperle, Mégan, additional, Brochu, Christian, additional, Gillard, James, additional, Joly, Marc-André, additional, Landry, Serge, additional, Lepage, Olivier, additional, Llinàs-Brunet, Montse, additional, Pesant, Marc, additional, Poirier, Martin, additional, Poirier, Maude, additional, McKercher, Ginette, additional, Marquis, Martin, additional, Kukolj, George, additional, Beaulieu, Pierre L., additional, and Stammers, Timothy A., additional

Published
2013
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5. Practical Synthesis of A Benzophenone-Based NNRT Inhibitor of HIV-1

Author

Wang, Xiao-jun, primary, Zhang, Li, additional, Sun, Xiufeng, additional, Lee, Heewon, additional, Krishnamurthy, Dhileepkumar, additional, O’Meara, Jeff A., additional, Landry, Serge, additional, Yoakim, Christiane, additional, Simoneau, Bruno, additional, Yee, Nathan K., additional, and Senanayake, Chris H., additional

Published
2012
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6. Novel 8-Substituted Dipyridodiazepinone Inhibitors with a Broad-Spectrum of Activity against HIV-1 Strains Resistant to Non-nucleoside Reverse Transcriptase Inhibitors

Author

O'Meara, Jeff A., primary, Yoakim, Christiane, additional, Bonneau, Pierre R., additional, Bös, Michael, additional, Cordingley, Michael G., additional, Déziel, Robert, additional, Doyon, Louise, additional, Duan, Jianmin, additional, Garneau, Michel, additional, Guse, Ingrid, additional, Landry, Serge, additional, Malenfant, Eric, additional, Naud, Julie, additional, Ogilvie, William W., additional, Thavonekham, Bounkham, additional, and Simoneau, Bruno, additional

Published
2005
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11. Synthesis of Propionate Motifs: Diastereoselective Tandem Reactions Involving Anionic and Free Radical Based Processes [J. Am. Chem. Soc. 2001, 123 (35), 8496−8501]

Author

Benoit Cardinal-David, Yvan Guindon, Landry Serge, and Mohammed Bencheqroun, Brigitte Guérin, Benoit Daoust, Karine Houde, and Michel Prévost

Subjects
chemistry.chemical_classification, Colloid and Surface Chemistry, chemistry, Tandem, Propionate, Organic chemistry, General Chemistry, Biochemistry, Catalysis
Published
2002
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