1. Circulating Human Monocytes in the Acute Coronary Syndrome Express a Characteristic Proteomic Profile
- Author
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Maria G. Barderas, José J. Jiménez-Nácher, Verónica M. Darde, Nieves Tarín, Lorenzo López-Bescós, Jesús Egido, Fernando Vivanco, José Tuñón, Maria C. Duran, and Fernando de la Cuesta
- Subjects
Male ,Proteomics ,Spectrometry, Mass, Electrospray Ionization ,Acute coronary syndrome ,Coronary Disease ,Coronary disease ,Coronary Angiography ,Biochemistry ,Monocytes ,Coronary artery disease ,medicine ,Humans ,Aged ,Proteomic Profile ,business.industry ,Patient Selection ,Monocyte ,Blood Proteins ,General Chemistry ,Middle Aged ,medicine.disease ,Blood proteins ,Enzymes ,medicine.anatomical_structure ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Immunology ,Proteome ,Female ,business - Abstract
We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed progressively, and at 6 months, there were no differences with the monocyte proteome of stable patients.
- Published
- 2006
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