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Your search keyword '"Pan, Pei"' showing total 10 results
Start Over Author "Pan, Pei" Publisher american chemical society (acs)
10 results on '"Pan, Pei"'

2. Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid Conjugate

Author

Lo, Chen-Fu, primary, Chiu, Tai-Yu, additional, Liu, Yu-Tzu, additional, Pan, Pei-Yun, additional, Liu, Kuan-Liang, additional, Hsu, Chia-Yu, additional, Fang, Ming-Yu, additional, Huang, Yu-Chen, additional, Yeh, Teng-Kuang, additional, Hsu, Tsu-An, additional, Chen, Chiung-Tong, additional, Huang, Li-Rung, additional, and Tsou, Lun Kelvin, additional

Published
2022
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3. A General and Modular Access to Enantioenriched α Trifluoromethyl Ketones via Nickel-Catalyzed Reductive Cross-Coupling

Author

Liang-An Chen, Dengkai Lin, Yongzhi Chen, Zhan Dong, Pan Pei, Haiting Ji, and Lanzhu Tai

Abstract

The development of new catalytic enantioselective access to CF3-containing stereogenicity is of great interest for the expediting discovery of lead compounds yet remains challenging. We devised a general and modular approach to facilely access enantioenriched α-CF3 ketones via nickel-catalyzed reductive cross-coupling of readily available acid chlorides and racemic α-CF3 alkyl bromides in an enantioconvergent fashion under mild conditions. This protocol featured neighboring directing group-free, high chemoselectivity, excellent functional group tolerance, facile scale-up, and notable amenability to straightforward downstream elaboration toward molecule complexity, thus constituting a reliable, direct, practical, and efficient synthetic alternative to furnish enantiopure α-CF3 carbonyls. Interestingly, an appropriate choice of the phosphine ligand as co-ligand plays an important role in high efficiency and asymmetric induction. Mechanistic studies suggest a radical chain pathway.

Published
2022

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