1. Polystyrene:β-Cyclodextrin Inclusion Complex-Supported Y2O3-Based Electrochemical Sensor: Effective and Simultaneous Determination of 4-Aminoantipyrine and Acyclovir Drugs
- Author
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Palraj Ranganathan, Pedaballi Sireesha, Bhuvanenthiran Mutharani, and Shen-Ming Chen
- Subjects
Positive shift ,Detection limit ,chemistry.chemical_classification ,Cyclodextrin ,Oxide ,virus diseases ,chemistry.chemical_element ,02 engineering and technology ,Yttrium ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Catalysis ,Electrochemical gas sensor ,chemistry.chemical_compound ,General Energy ,chemistry ,Polystyrene ,Physical and Theoretical Chemistry ,0210 nano-technology ,Nuclear chemistry - Abstract
In this study, a novel polystyrene:β-cyclodextrin inclusion complex-supported yttrium oxide (Y2O3)-modified glassy carbon electrode (PS:β-CD IC/Y2O3/GCE) was developed for the simultaneous determination of selected drugs, 4-aminoantipyrine (4-AAP) and acyclovir (ACV) for the first time. The results showed that PS:β-CD IC/Y2O3/GCE exhibits well-defined oxidation peak currents with a lower positive shift in peak potential in the simultaneous determination of 4-AAP and ACV compared to the bare GCE, demonstrating the superior catalytic activity. The fabricated sensor showed the linear ranges of 0.01–655 and 0.01–918 μM with low detection limits of 0.01 and 0.02 μM for the determination of 4-AAP and ACV, respectively. Further, the as-prepared PS:β-CD IC/Y2O3/GCE has been applied to the simultaneous and individual determination of 4-AAP and ACV in human urine and commercial ACV tablet samples with satisfactory recovery (98–99.3 and 88–96.6%), thereby showing a notable potential for extensive applications in the...
- Published
- 2019
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