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Your search keyword '"Ryo Nakatani"' showing total 2 results
Start Over Author "Ryo Nakatani" Publisher american chemical society (acs)
2 results on '"Ryo Nakatani"'

1. Asymmetric Total Synthesis of (+)-Hexachlorosulfolipid, a Cytotoxin Isolated from Adriatic Mussels

Author

Tetsuaki Tanaka, Naoto Kojima, Ryo Nakatani, Naoya Fukumoto, and Takehiko Yoshimitsu

Subjects
Mytilus, In situ, animal structures, biology, Chemistry, Stereochemistry, fungi, Organic Chemistry, Molecular Conformation, Enantioselective synthesis, Absolute configuration, Total synthesis, Epoxide, Stereoisomerism, Mussel, biology.organism_classification, Lipids, chemistry.chemical_compound, Reagent, Animals, Computer Simulation
Abstract

The enantioselective total synthesis of (+)-hexachlorosulfolipid, a cytotoxin found in the Adriatic mussel Mytilus galloprovincialis, is described. The unique chlorinated hydrocarbon motif of the lipid is successfully furnished by a series of dichlorination reactions of chiral epoxides with chlorophosphonium reagent generated in situ from Ph(3)P/NCS. The present total synthesis has allowed the confirmation of the absolute configuration of the natural cytotoxic (+)-hexachlorosulfolipid originally proposed by Fattorusso, Ciminiello, and co-workers.

Published
2010
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2. Concise Total Synthesis of (−)-Spongotine A

Author

Ozora Kubo, Kenichi Murai, Yasuyuki Kita, Hiromichi Fujioka, Ryo Nakatani, and Maiko Morishita

Subjects
chemistry.chemical_classification, Ketone, Molecular Structure, Stereochemistry, Organic Chemistry, Enantioselective synthesis, Absolute configuration, Imidazoline receptor, Total synthesis, Stereoisomerism, Aldehyde, Chemical synthesis, Indole Alkaloids, chemistry.chemical_compound, chemistry, Diamine, Combinatorial Chemistry Techniques, Imidazolines
Abstract

The first asymmetric total synthesis of spongotine A is described. The oxidative synthesis of the imidazoline/ketone unit from keto aldehyde and diamine is a key step in this synthesis. The absolute stereochemistry of the asymmetric center of natural spongotine A is revealed as the (S)-configuration.

Published
2007
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