1. Rhodium-Catalyzed Enantioselective Isomerization of Secondary Allylic Alcohols
- Author
-
Tang-Lin Liu, Yu Zhao, and Teng Wei Ng
- Subjects
chemistry.chemical_classification ,Allylic rearrangement ,Ketone ,010405 organic chemistry ,Chemistry ,Enantioselective synthesis ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,0104 chemical sciences ,Stereocenter ,Rhodium ,Colloid and Surface Chemistry ,Organic chemistry ,Stereoselectivity ,Isomerization - Abstract
The first catalytic enantioselective isomerization of secondary allylic alcohols to access ketones with a α-tertiary stereocenter is presented. The racemic allylic alcohol substrates can be converted to the enantioenriched ketone products in a stereoconvergent fashion. The use of commercially available catalysts and mild reaction conditions makes this an attractive method in stereoselective synthesis.
- Published
- 2017