1. Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers
- Author
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Miriam Barthelmess, Leonard M. G. Chavas, Andrew J. Morgan, Michael Heymann, H. Fleckenstein, Niko Eckerskorn, Max O. Wiedorn, M. Domaracky, Juraj Knoska, Richard Bean, Luigi Adriano, Andrei Rode, Nils Roth, Richard A. Kirian, Markus Metz, Tokushi Sato, O. Yefanov, Dominik Oberthuer, Salah Awel, Daniel A. Horke, Jochen Küpper, Paulraj Lourdu Xavier, Henry N. Chapman, Kenneth R. Beyerlein, and Saša Bajt
- Subjects
Free electron model ,Radiation ,Atmospheric pressure ,business.industry ,Nozzle ,Nanotechnology ,Injector ,Invited Articles ,Condensed Matter Physics ,Laser ,SPECIAL TOPIC: BIOLOGY WITH X-RAY LASERS 2 ,3. Good health ,law.invention ,Aerosol ,Optics ,law ,lcsh:QD901-999 ,Particle ,ddc:530 ,lcsh:Crystallography ,business ,Instrumentation ,Spectroscopy ,Beam (structure) - Abstract
A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.
- Published
- 2015
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