7 results on '"Gengler, Nicolas"'
Search Results
2. Genetic analysis of milk citrate predicted by milk mid-infrared spectra of Holstein cows in early lactation
- Author
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Chen, Yansen, primary, Hu, Hongqing, additional, Atashi, Hadi, additional, Grelet, Clément, additional, Wijnrocx, Katrien, additional, Lemal, Pauline, additional, and Gengler, Nicolas, additional
- Published
- 2023
- Full Text
- View/download PDF
3. Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle
- Author
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Negussie, Enyew, González-Recio, Oscar, Battagin, Mara, Bayat, Ali-Reza, Boland, Tommy M., de Haas, Yvette, García-Rodríguez, Aser, Garnsworthy, P. C., Gengler, Nicolas, Kreuzer, Michael, Kuhla, Björn, Lassen, Jan, Peiren, Nico, Pszczola, Marcin, Schwarm, Angela, Soyeurt, Hélène, Vanlierde, Amélie, Yan, Tianhai, Biscarini, Filippo, European Commission, Negussie, Enyew [0000-0003-4892-9938], González-Recio, Oscar [0000-0002-9106-4063], Battagin, Mara [0000-0001-7309-6793], Bayat, Ali-Reza [0000-0002-4894-0662], Boland, Tommy [0000-0002-7433-130X], de Haas, Yvette [0000-0002-4331-4101], Garcia-Rodriguez, Aser [0000-0001-5519-6766], Garnsworthy, Philip C [0000-0001-5131-3398], Gengler, Nicolas [0000-0002-5981-5509], Kreuzer, Michael [0000-0002-9978-1171], Kuhla, Björn [0000-0002-2032-5502, Lassen, Jan [0000-0002-1338-8644], Peiren, Nico [0000-0001-5500-1607], Pszczola, Marcin [0000-0003-2833-5083], Schwarm, Angela [0000-0002-5750-2111], Soyeurt, Hélène [0000-0001-9883-9047], Vanlierde, Amélie [0000-0002-4619-1936], Yan, Tianhai [0000-0002-1994-5202], Biscarini, Filippo [0000-0002-3901-2354], Negussie, Enyew, González-Recio, Oscar, Battagin, Mara, Bayat, Ali-Reza, Boland, Tommy, de Haas, Yvette, Garcia-Rodriguez, Aser, Garnsworthy, Philip C, Gengler, Nicolas, Kreuzer, Michael, Kuhla, Björn, Lassen, Jan, Peiren, Nico, Pszczola, Marcin, Schwarm, Angela, Soyeurt, Hélène, Vanlierde, Amélie, Yan, Tianhai, and Biscarini, Filippo
- Subjects
methane emissions ,Enteric methane ,proxies ,Prediction models ,predictive model ,Intestine, Small ,Machine learning ,Genetics ,Animals ,Lactation ,dairy cows ,Fokkerij & Genomica ,prediction models ,Proxies for methane ,Diet ,Milk ,machine learning ,WIAS ,enteric methane ,proxies for methane ,Cattle ,Female ,Animal Science and Zoology ,Methane ,random forest ,Animal Breeding & Genomics ,Food Science - Abstract
Direct measurements of methane (CH4) from individual animals are difficult and expensive. Predictions based on proxies for CH4 are a viable alternative. Most prediction models are based on multiple linear regressions (MLR) and predictor variables that are not routinely available in commercial farms, such as dry matter intake (DMI) and diet composition. The use of machine learning (ML) algorithms to predict CH4 emissions from across-country heterogeneous data sets has not been reported. The objectives were to compare performances of ML ensemble algorithm random forest (RF) and MLR models in predicting CH4 emissions from proxies in dairy cows, and assess effects of imputing missing data points on prediction accuracy. Data on CH4 emissions and proxies for CH4 from 20 herds were provided by 10 countries. The integrated data set contained 43,519 records from 3,483 cows, with 18.7% missing data points imputed using k-nearest neighbor imputation. Three data sets were created, 3k (no missing records), 21k (missing DMI imputed from milk, fat, protein, body weight), and 41k (missing DMI, milk fat, and protein records imputed). These data sets were used to test scenarios (with or without DMI, imputed vs. nonimputed DMI, milk fat, and protein), and prediction models (RF vs. MLR). Model predictive ability was evaluated within and between herds through 10-fold cross-validation. Prediction accuracy was measured as correlation between observed and predicted CH4, root mean squared error (RMSE) and mean normalized discounted cumulative gain (NDCG). Inclusion of DMI in the model improved within and between-herd prediction accuracy to 0.77 (RMSE = 23.3%) and 0.58 (RMSE = 31.9%) in RF and to 0.50 (RMSE = 0.327) and 0.13 (RMSE = 42.71) in MLR, respectively than when DMI was not included in the predictive model. When missing DMI records were imputed, within and between-herd accuracy increased to 0.84 (RMSE = 18.5%) and 0.63 (RMSE = 29.9%), respectively. In all scenarios, RF models out-performed MLR models. Results suggest routinely measured variables from dairy farms can be used in developing globally robust prediction models for CH4 if coupled with state-of-the-art techniques for imputation and advanced ML algorithms for predictive modeling., Journal of Dairy Science, 105 (6), ISSN:0022-0302, ISSN:1525-3198
- Published
- 2022
4. Short communication: Investigation of the temporal relationships between milk mid-infrared predicted biomarkers and lameness events in later lactation
- Author
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Mineur, Axelle, primary, Hammami, Hedi, additional, Grelet, Clément, additional, Egger-Danner, Christa, additional, Sölkner, Johann, additional, and Gengler, Nicolas, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Exploring a Bayesian sparse factor model-based strategy for the genetic analysis of thousands of MIR-spectra traits for animal breeding.
- Author
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Chen Y, Atashi H, Qu J, Delhez P, Runcie D, Soyeurt H, and Gengler N
- Abstract
With the rapid development of animal phenomics and deep phenotyping, we can get thousands of traditional but also molecular phenotypes per individual. However, there is still a lack of exploration regarding how to handle this huge amount of data in the context of animal breeding, presenting a challenge that we are likely to encounter more and more in the future. This study aimed to (1) explore the use of the Mega-scale linear mixed model (MegaLMM), a factor model-based approach, able to simultaneously estimate (co)variance components and genetic parameters in the context of thousands of milk traits, hereafter called thousand-trait (TT) models; (2) compare the phenotype values and genomic breeding values (u) predictions for focal traits (i.e., traits that are targeted for prediction, compared with secondary traits that are helping to evaluate), from single-trait (ST) and TT models, respectively; (3) propose a new approximate method of estimated genomic breeding values (U) prediction with TT models and MegaLMM. 3,421 milk mid-infrared (MIR) spectra wavepoints (called secondary traits) and 3 focal traits [average fat percent (Fat), average methane (CH4), and average somatic cell score (SCS)] collected on 3,302 first-parity Holstein cows were used. The 3,421 milk MIR wavepoints traits were composed of 311 wavepoints in 11 classes (months in lactation). Genotyping information of 564,439 SNP was available for all animals and was used to calculate the genomic relationship matrix. The MegaLMM was implemented in the framework of the Bayesian sparse factor model and solved through Gibbs sampling (Markov chain Monte Carlo). The heritabilities of the studied 3,421 milk MIR wavepoints gradually increased and then decreased in units of 311 wavepoints throughout the lactation. The genetic and phenotypic correlations between the first 311 wavepoints and the other 3,110 wavepoints were low. The accuracies of phenotype predictions from the ST model were lower than those from the TT model for Fat (0.51 vs. 0.93), CH4 (0.30 vs. 0.86), and SCS (0.14 vs. 0.33). The same trend was observed for the accuracies of u predictions: Fat (0.59 vs. 0.86), CH4 (0.47 vs. 0.78), and SCS (0.39 vs. 0.59). The average correlation between U predicted from the TT model and the new approximate method was 0.90. The new approximate method used for estimating U in MegaLMM will enhance the suitability of MegaLMM for applications in animal breeding. This study conducted an initial investigation into the application of thousands of traits in animal breeding and showed that the TT model is beneficial for the prediction of focal traits (phenotype and breeding values), especially for difficult-to-measure traits (e.g., CH4)., (The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)
- Published
- 2024
- Full Text
- View/download PDF
6. Genetic analysis of milk citrate predicted by milk mid-infrared spectra of Holstein cows in early lactation.
- Author
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Chen Y, Hu H, Atashi H, Grelet C, Wijnrocx K, Lemal P, and Gengler N
- Subjects
- Pregnancy, Female, Cattle genetics, Animals, Lactation genetics, Phenotype, Quantitative Trait Loci, Citrates, Milk metabolism, Citric Acid metabolism
- Abstract
Milk citrate is regarded as an early biomarker of negative energy balance in dairy cows during early lactation and serves as a suitable candidate phenotype for genomic selection due to its wide availability across a large number of cows through milk mid-infrared spectra prediction. However, its genetic background is not well known. Therefore, the objectives of this study were to (1) analyze the genetic parameters of milk citrate; (2) identify genomic regions associated with milk citrate; and (3) analyze the functional annotation of candidate genes and quantitative trait loci (QTL) related to milk citrate in Walloon Holstein cows. In total, 134,517 test-day milk-citrate phenotypes (mmol/L) collected within the first 50 d in milk on 52,198 Holstein cows were used. These milk-citrate phenotypes, predicted by milk mid-infrared spectra, were divided into 3 traits according to the first (citrate1), second (citrate2), and third to fifth parity (citrate3+). Genomic information for 566,170 SNPs was available for 4,479 animals. A multiple-trait repeatability model was used to estimate genetic parameters. A single-step GWAS was used to identify candidate genes for citrate and post-GWAS analysis was done to investigate the relationship and function of the identified candidate genes. The heritabilities estimated for citrate1, citrate2, and citrate3+ were 0.40, 0.37, and 0.35, respectively. The genetic correlations among the 3 traits ranged from 0.98 to 0.99. The genomic correlations among the 3 traits were also close to 1.00 across the genomic regions (1 Mb) in the whole genome, which means that citrate can be considered as a single trait in the first 5 parities. In total, 603 significant SNPs located on 3 genomic regions (chromosome 7, 68.569-68.575 Mb; chromosome 14, 0.15-1.90 Mb; and chromosome 20, 54.00-64.28 Mb), were identified to be associated with milk citrate. We identified 89 candidate genes including GPT, ANKH, PPP1R16A, and 32 QTL reported in the literature related to the identified significant SNPs. These identified QTL were mainly reported associated with milk fatty acids and metabolic diseases in dairy cows. This study suggests that milk citrate in Holstein cows is highly heritable and has the potential to be used as an early proxy for the negative energy balance of Holstein cows in a breeding objective., (The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)
- Published
- 2024
- Full Text
- View/download PDF
7. Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle.
- Author
-
Negussie E, González-Recio O, Battagin M, Bayat AR, Boland T, de Haas Y, Garcia-Rodriguez A, Garnsworthy PC, Gengler N, Kreuzer M, Kuhla B, Lassen J, Peiren N, Pszczola M, Schwarm A, Soyeurt H, Vanlierde A, Yan T, and Biscarini F
- Subjects
- Animals, Cattle, Diet veterinary, Female, Intestine, Small metabolism, Milk chemistry, Lactation, Methane metabolism
- Abstract
Direct measurements of methane (CH
4 ) from individual animals are difficult and expensive. Predictions based on proxies for CH4 are a viable alternative. Most prediction models are based on multiple linear regressions (MLR) and predictor variables that are not routinely available in commercial farms, such as dry matter intake (DMI) and diet composition. The use of machine learning (ML) algorithms to predict CH4 emissions from across-country heterogeneous data sets has not been reported. The objectives were to compare performances of ML ensemble algorithm random forest (RF) and MLR models in predicting CH4 emissions from proxies in dairy cows, and assess effects of imputing missing data points on prediction accuracy. Data on CH4 emissions and proxies for CH4 from 20 herds were provided by 10 countries. The integrated data set contained 43,519 records from 3,483 cows, with 18.7% missing data points imputed using k-nearest neighbor imputation. Three data sets were created, 3k (no missing records), 21k (missing DMI imputed from milk, fat, protein, body weight), and 41k (missing DMI, milk fat, and protein records imputed). These data sets were used to test scenarios (with or without DMI, imputed vs. nonimputed DMI, milk fat, and protein), and prediction models (RF vs. MLR). Model predictive ability was evaluated within and between herds through 10-fold cross-validation. Prediction accuracy was measured as correlation between observed and predicted CH4 , root mean squared error (RMSE) and mean normalized discounted cumulative gain (NDCG). Inclusion of DMI in the model improved within and between-herd prediction accuracy to 0.77 (RMSE = 23.3%) and 0.58 (RMSE = 31.9%) in RF and to 0.50 (RMSE = 0.327) and 0.13 (RMSE = 42.71) in MLR, respectively than when DMI was not included in the predictive model. When missing DMI records were imputed, within and between-herd accuracy increased to 0.84 (RMSE = 18.5%) and 0.63 (RMSE = 29.9%), respectively. In all scenarios, RF models out-performed MLR models. Results suggest routinely measured variables from dairy farms can be used in developing globally robust prediction models for CH4 if coupled with state-of-the-art techniques for imputation and advanced ML algorithms for predictive modeling., (© 2022, The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)- Published
- 2022
- Full Text
- View/download PDF
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