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Your search keyword '"Coskun, Tamer"' showing total 18 results
Start Over Author "Coskun, Tamer" Publisher american diabetes association
18 results on '"Coskun, Tamer"'

1. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice

Author

C Furber, Ellen, primary, Hyatt, Karissa, primary, Collins, Kyla, primary, Yu, Xinxin, primary, A Droz, Brian, primary, Holland, Adrienne, primary, L. Friedrich, Jessica, primary, Wojnicki, Samantha, primary, L Konkol, Debra, primary, S O'Farrell, Libbey, primary, E Baker, Hana, primary, Coskun, Tamer, primary, E Scherer, Philipp, primary, M Kusminski, Christine, primary, E Christe, Michael, primary, W Sloop, Kyle, primary, and J Samms, Ricardo, primary

Published
2023
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2. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice

Author

Furber, Ellen C, primary, Hyatt, Karissa, additional, Collins, Kyla, additional, Yu, Xinxin, additional, Droz, Brian A, additional, Holland, Adrienne, additional, Friedrich, Jessica L., additional, Wojnicki, Samantha, additional, Konkol, Debra L, additional, O’Farrell, Libbey S, additional, Baker, Hana E, additional, Coskun, Tamer, additional, Scherer, Philipp E, additional, Kusminski, Christine M, additional, Christe, Michael E, additional, Sloop, Kyle W, additional, and Samms, Ricardo J, additional

Published
2023
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3. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.

Author

Furber, Ellen C., Hyatt, Karissa, Collins, Kyla, Yu, Xinxin, Droz, Brian A., Holland, Adrienne, Friedrich, Jessica L., Wojnicki, Samantha, Konkol, Debra L., O’Farrell, Libbey S., Baker, Hana E., Coskun, Tamer, Scherer, Philipp E., Kusminski, Christine M., Christe, Michael E., Sloop, Kyle W., and Samms, Ricardo J.

Subjects
INSULIN sensitivity, GLUCAGON-like peptide-1 receptor, BROWN adipose tissue, WEIGHT gain, GLUCAGON-like peptide-1 agonists
Abstract

Recent studies have found that glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism can enhance the metabolic efficacy of glucagon-like peptide–1 receptor agonist treatment by promoting both weight-dependent and -independent improvements on systemic insulin sensitivity. These findings have prompted new investigations aimed at better understanding the broad metabolic benefit of GIPR activation. Herein, we determined whether GIPR agonism favorably influenced the pharmacologic efficacy of the insulin-sensitizing thiazolidinedione (TZD) rosiglitazone in obese insulin-resistant (IR) mice. Genetic and pharmacological approaches were used to examine the role of GIPR signaling on rosiglitazone-induced weight gain, hyperphagia, and glycemic control. RNA sequencing was conducted to uncover potential mechanisms by which GIPR activation influences energy balance and insulin sensitivity. In line with previous findings, treatment with rosiglitazone induced the mRNA expression of the GIPR in white and brown fat. However, obese GIPR-null mice dosed with rosiglitazone had equivalent weight gain to that of wild-type (WT) animals. Strikingly, chronic treatment of obese IR WT animals with a long-acting GIPR agonist prevented rosiglitazone-induced weight-gain and hyperphagia, and it enhanced the insulin-sensitivity effect of this TZD. The systemic insulin sensitization was accompanied by increased glucose disposal in brown adipose tissue, which was underlined by the recruitment of metabolic and thermogenic genes. These findings suggest that GIPR agonism can counter the negative consequences of rosiglitazone treatment on body weight and adiposity, while improving its insulin-sensitizing efficacy at the same time. Article Highlights: Body weight gain resulting from treatment with the insulin-sensitizing thiazolidinedione rosiglitazone does not require the glucose-dependent insulinotropic polypeptide receptor (GIPR). Treatment with a GIPR agonist prevents the hyperphagic and obesogenic activity of rosiglitazone. Activation of the GIPR improves the insulin-sensitizing actions of rosiglitazone. [ABSTRACT FROM AUTHOR]

Published
2024
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9. GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

Author

Samms, Ricardo J, primary, Cosgrove, Richard, primary, Snider, Brandy M, primary, Furber, Ellen C, primary, Droz, Brian A, primary, Briere, Daniel A, primary, Dunbar, James, primary, Dogra, Mridula, primary, Alsina-Fernandez, Jorge, primary, Borner, Tito, primary, Jonghe, Bart C. De, primary, Hayes, Matthew R., primary, Coskun, Tamer, primary, Sloop, Kyle W, primary, Emmerson, Paul J, primary, and Ai, Minrong, primary

Published
2022
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10. GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

Author

Samms, Ricardo J., primary, Cosgrove, Richard, additional, Snider, Brandy M., additional, Furber, Ellen C., additional, Droz, Brian A., additional, Briere, Daniel A., additional, Dunbar, James, additional, Dogra, Mridula, additional, Alsina-Fernandez, Jorge, additional, Borner, Tito, additional, De Jonghe, Bart C., additional, Hayes, Matthew R., additional, Coskun, Tamer, additional, Sloop, Kyle W., additional, Emmerson, Paul J., additional, and Ai, Minrong, additional

Published
2022
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11. 639-P: GIP Receptor Agonism Enhances Weight Loss from Either a Biased or an Unbiased GLP-1 Receptor Agonist in DIO Mice

Author

COGHLAN, MATTHEW P., primary, O’FARRELL, LIBBEY, additional, SHOWALTER, AARON D., additional, WAINSCOTT, DAVID B., additional, STUTSMAN, CYNTHIA, additional, CARDONA, GUEMALLI, additional, CABRERA, OVER, additional, ALSINA-FERNANDEZ, JORGE, additional, WILLARD, FRANCIS S., additional, SLOOP, KYLE, additional, and COSKUN, TAMER, additional

Published
2021
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13. 679-P: The Novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943 Exhibits Robust Efficacy in Preclinical Models of Obesity and Diabetes

Author

COSKUN, TAMER, primary, MOYERS, JULIE S., additional, ROELL, WILLIAM C., additional, O’FARRELL, LIBBEY, additional, REGMI, AJIT, additional, RUAN, XIAOPING, additional, SHOWALTER, AARON D., additional, SLOOP, KYLE, additional, WAINSCOTT, DAVID B., additional, WILLARD, FRANCIS S., additional, FICORILLI, JAMES V., additional, CABRERA, OVER, additional, URVA, SHWETA, additional, COOPER, FARIBA NOROUZIYAN, additional, GUO, LILI, additional, ALSINA-FERNANDEZ, JORGE, additional, and QU, HONGCHANG, additional

Published
2021
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14. 682-P: Novel Dual Glucagon and Glucagon-Like Peptide-1 Receptor Agonist LY3305677 Improves Glucose Control, Reduces Body Weight, and Increases Energy Expenditure in Mice

Author

CHEN, YANYUN, primary, MEZO, ADAM, additional, COSKUN, TAMER, additional, SONG, MIN, additional, ROELL, WILLIAM C., additional, BOKVIST, KRISTER B., additional, MOYERS, JULIE S., additional, THOMAS, MELISSA K., additional, VALENZUELA, FRANCISCO, additional, and QU, HONGCHANG, additional

Published
2021
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15. 142-OR: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Mediates Its Anorexigenic Effect in Mice Due to a Reduction in Homeostatic and Reward-Related Feeding

Author

COSGROVE, RICHARD, primary, ANTONELLIS, MEGHAN P., additional, DROZ, BRIAN, additional, ROELL, WILLIAM C., additional, SLOOP, KYLE, additional, MOYERS, JULIE, additional, COGHLAN, MATTHEW P., additional, EMMERSON, PAUL, additional, COSKUN, TAMER, additional, and SAMMS, RICARDO J., additional

Published
2020
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17. Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice

Author

Borg, Melissa L., primary, Massart, Julie, additional, Schönke, Milena, additional, De Castro Barbosa, Thais, additional, Guo, Lili, additional, Wade, Mark, additional, Alsina-Fernandez, Jorge, additional, Miles, Rebecca, additional, Ryan, Andrew, additional, Bauer, Steve, additional, Coskun, Tamer, additional, O’Farrell, Elizabeth, additional, Niemeier, Evan M., additional, Chibalin, Alexander V., additional, Krook, Anna, additional, Karlsson, Håkan K., additional, Brozinick, Joseph T., additional, and Zierath, Juleen R., additional

Published
2019
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18. FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency

Author

Dollet, Lucile, primary, Levrel, Clara, additional, Coskun, Tamer, additional, Le Lay, Soazig, additional, Le May, Cedric, additional, Ayer, Audrey, additional, Venara, Quentin, additional, Adams, Andrew C., additional, Gimeno, Ruth E., additional, Magré, Jocelyne, additional, Cariou, Bertrand, additional, and Prieur, Xavier, additional

Published
2016
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