1. Osteoprotegerin, Thiazolidinediones Treatment, and Silent Myocardial Ischemia in Type 2 Diabetic Patients
- Author
-
Jean-Paul Cristol, Antoine Avignon, Ariane Sultan, Denis Mariano-Goulart, Christophe Piot, Anne Marie Dupuy, and Florence Galtier
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Myocardial Ischemia ,Blood Pressure ,Type 2 diabetes ,Asymptomatic ,Body Mass Index ,Myocardial perfusion imaging ,Sex Factors ,Osteoprotegerin ,Osteoclast ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Triglycerides ,Aged ,Glycated Hemoglobin ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Cholesterol, HDL ,Age Factors ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Dipyridamole ,Endocrinology ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,Creatinine ,Cardiology ,Female ,Thiazolidinediones ,medicine.symptom ,business ,medicine.drug - Abstract
Thiazolidinediones (TZDs) are widely prescribed for the treatment of type 2 diabetes. They were reported to have vasculoprotective properties like a reduction in carotid artery intima-media thickness progression (1) but may also reduce bone formation and favor bone loss (2,3). The decoy receptor osteoprotegerin, a member of the receptor activator of nuclear factor-κB ligand/osteoprotegerin system, involved in osteoclast development and function (4), might also be a regulator of vascular calcification and an indicator of vascular disease (5). In diabetic patients, this latter point is supported by our previous data showing a positive association between silent myocardial ischemia (SMI) and osteoprotegerin levels (6,7). We tested, in a case-control study, the a priori hypothesis that TZDs might be associated with decreased osteoprotegerin levels and lower prevalence of SMI in patients treated with TZDs. A total of 198 consecutive asymptomatic non–insulin-treated type 2 diabetes patients (age 60.1 ± 9.1, 68% male, A1C 8.1 ± 1.7%, BMI 30.7 ± 4.6 kg/m2) with one or more additional risk factor underwent SMI screening, using dipyridamole combined with exercise myocardial perfusion imaging (MPI) as previously described (6,7). SMI was defined as positive MPI (mean activity 1 mm). The 46 type 2 diabetic patients …
- Published
- 2008