1. Correlates of Age Onset of Type 2 Diabetes Among Relatively Young Black and White Adults in a Community
- Author
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Quoc Manh Nguyen, Jihua Xu, Gerald S. Berenson, Sathanur R. Srinivasan, and Wei Chen
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cardiovascular and Metabolic Risk ,Adolescent ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,Risk Assessment ,White People ,Body Mass Index ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Age of Onset ,Prospective cohort study ,Original Research ,Adiposity ,Advanced and Specialized Nursing ,Analysis of Variance ,business.industry ,Hazard ratio ,Middle Aged ,medicine.disease ,Louisiana ,3. Good health ,Black or African American ,Endocrinology ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Cohort ,Female ,Age of onset ,business ,Body mass index ,Diabetic Angiopathies ,Demography ,Cohort study - Abstract
OBJECTIVE The risk factors for middle-age onset of type 2 diabetes are well known. However, information is scant regarding the age onset of type 2 diabetes and its correlates in community-based black and white relatively young adults. RESEARCH DESIGN AND METHODS This prospective cohort study consisted of normoglycemic (n = 2,459) and type 2 diabetic (n = 144) adults aged 18–50 years who were followed for an average of 16 years. RESULTS The incidence rate of the onset of type 2 diabetes was 1.6, 4.3, 3.9, and 3.4 per 1,000 person-years for age-groups 18–29, 30–39, and 40–50 and total sample, respectively. Incidences of diabetes increased with age by race and sex groups (P for trend ≤0.01); higher in black females versus white females and blacks versus whites in total sample (P < 0.05). In a multivariable Cox model, baseline parental diabetes (hazard ratio [HR] 5.24) and plasma insulin were significantly associated with diabetes incidence at the youngest age (18–29 years); black race, BMI, and glucose at age 30–39 years; female sex, parental diabetes (HR 2.44), BMI, ratio of triglycerides and HDL cholesterol (TG/HDL-C ratio), and glucose at age 40–50 years; and black race, parental diabetes (HR 2.44), BMI, TG/HDL-C ratio, and glucose in whole cohort. Further, patients with diabetes, regardless of age onset, displayed a significantly higher prevalence of maternal history of diabetes at baseline (P < 0.01). CONCLUSIONS In relatively young adults, predictability of baseline cardiometabolic risk factors along with race, sex, and parental history of diabetes for the onset of type 2 diabetes varied by age-group. These findings have implications for early prevention and intervention in relatively young adults. more...
- Published
- 2012