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Your search keyword '"Leete, Pia"' showing total 11 results
Start Over Author "Leete, Pia" Publisher american diabetes association
11 results on '"Leete, Pia"'

1. Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration

Author

Carr, Alice L.J., primary, Inshaw, Jamie R.J., additional, Flaxman, Christine S., additional, Leete, Pia, additional, Wyatt, Rebecca C., additional, Russell, Lydia A., additional, Palmer, Matthew, additional, Prasolov, Dmytro, additional, Worthington, Thomas, additional, Hull, Bethany, additional, Wicker, Linda S., additional, Dunger, David B., additional, Oram, Richard A., additional, Morgan, Noel G., additional, Todd, John A., additional, Richardson, Sarah J., additional, and Besser, Rachel E.J., additional

Published
2022
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2. Circulating C-Peptide Levels in Living Children and Young People and Pancreatic Beta Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration

Author

Carr, Alice L.J., primary, Inshaw, Jamie R.J., primary, Flaxman, Christine S., primary, Leete, Pia, primary, Wyatt, Rebecca C., primary, Russell, Lydia A., primary, Palmer, Matthew, primary, Prasolov, Dmytro, primary, Worthington, Thomas, primary, Hull, Bethany, primary, Wicker, Linda S., primary, Dunger, David B., primary, Oram, Richard A., primary, Morgan, Noel G., primary, Todd, John A., primary, Richardson, Sarah J., primary, and Besser, Rachel E.J., primary

Published
2022
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3. Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes

Author

Rodriguez-Calvo, Teresa, primary, Chen, Yi-Chun, additional, Verchere, C. Bruce, additional, Haataja, Leena, additional, Arvan, Peter, additional, Leete, Pia, additional, Richardson, Sarah J., additional, Morgan, Noel G., additional, Qian, Wei-Jun, additional, Pugliese, Alberto, additional, Atkinson, Mark, additional, Evans-Molina, Carmella, additional, and Sims, Emily K., additional

Published
2021
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4. HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Author

Russell, Mark A., primary, Redick, Sambra D., additional, Blodgett, David M., additional, Richardson, Sarah J., additional, Leete, Pia, additional, Krogvold, Lars, additional, Dahl-Jørgensen, Knut, additional, Bottino, Rita, additional, Brissova, Marcela, additional, Spaeth, Jason M., additional, Babon, Jenny Aurielle B., additional, Haliyur, Rachana, additional, Powers, Alvin C., additional, Yang, Chaoxing, additional, Kent, Sally C., additional, Derr, Alan G., additional, Kucukural, Alper, additional, Garber, Manuel G., additional, Morgan, Noel G., additional, and Harlan, David M., additional

Published
2019
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6. Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes.

Author

Krogvold, Lars, Edwin, Bjørn, Buanes, Trond, Frisk, Gun, Skog, Oskar, Anagandula, Mahesh, Korsgren, Olle, Undlien, Dag, Eike, Morten C, Richardson, Sarah J, Leete, Pia, Morgan, Noel G, Oikarinen, Sami, Oikarinen, Maarit, Laiho, Jutta E, Hyöty, Heikki, Ludvigsson, Johnny, Hanssen, Kristian F, Dahl-Jørgensen, Knut, Krogvold, Lars, Edwin, Bjørn, Buanes, Trond, Frisk, Gun, Skog, Oskar, Anagandula, Mahesh, Korsgren, Olle, Undlien, Dag, Eike, Morten C, Richardson, Sarah J, Leete, Pia, Morgan, Noel G, Oikarinen, Sami, Oikarinen, Maarit, Laiho, Jutta E, Hyöty, Heikki, Ludvigsson, Johnny, Hanssen, Kristian F, and Dahl-Jørgensen, Knut

Abstract

The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in 6 adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh frozen whole pancreatic tissue using PCR and sequencing. Non-diabetic organ donors served as controls. VP1 was detected in the islets of all type 1 diabetes patients (2 of 9 controls). Hyperexpression of class I HLA molecules was found in the islets of all patients (1 of 9 controls). Enterovirus specific RNA sequences were detected in 4 of 6 cases (0 of 6 controls). The results were confirmed in different laboratories. Only 1.7 % of the islets contained VP1 positive cells and the amount of enterovirus RNA was low. The results provides evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, being consistent with the possibility that a low grade enteroviral infection in the pancreatic islets contribute to disease progression in humans.

Published
2015
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7. C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

Author

Shields, Beverley M., McDonald, Timothy J., Oram, Richard, Hill, Anita, Hudson, Michelle, Leete, Pia, Pearson, Ewan R., Richardson, Sarah J., Morgan, Noel G., Hattersley, Andrew T., and TIGI Consortium

Subjects
TYPE 1 diabetes, C-peptide, TREATMENT of diabetes, CHRONIC diseases, AUTOIMMUNITY, DIAGNOSIS, THERAPEUTICS, BIOCHEMISTRY, BLOOD testing, COMPARATIVE studies, LONGITUDINAL method, PHENOMENOLOGY, RESEARCH methodology, MEDICAL cooperation, RESEARCH, RESEARCH funding, TIME, EVALUATION research, CROSS-sectional method, DISEASE progression
Abstract

Objective: The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We aimed to examine the association between log-transformed C-peptide levels and the duration of diabetes up to 40 years after diagnosis.Research Design and Methods: We assessed the pattern of association between urinary C-peptide/creatinine ratio (UCPCR) and duration of diabetes in cross-sectional data from 1,549 individuals with type 1 diabetes using nonlinear regression approaches. Findings were replicated in longitudinal follow-up data for both UCPCR (n = 161 individuals, 326 observations) and plasma C-peptide (n = 93 individuals, 473 observations).Results: We identified two clear phases of C-peptide decline: an initial exponential fall over 7 years (47% decrease/year [95% CI -51, -43]) followed by a stable period thereafter (+0.07%/year [-1.3, +1.5]). The two phases had similar durations and slopes in patients above and below the median age at diagnosis (10.8 years), although levels were lower in the younger patients irrespective of duration. Patterns were consistent in both longitudinal UCPCR (n = 162; ≤7 years duration: -48%/year [-55, -38]; >7 years duration -0.1% [-4.1, +3.9]) and plasma C-peptide (n = 93; >7 years duration only: -2.6% [-6.7, +1.5]).Conclusions: These data support two clear phases of C-peptide decline: an initial exponential fall over a 7-year period, followed by a prolonged stabilization where C-peptide levels no longer decline. Understanding the pathophysiological and immunological differences between these two phases will give crucial insights into understanding β-cell survival. [ABSTRACT FROM AUTHOR]

Published
2018
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8. Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835–3845

Author

Arif, Sefina, primary, Leete, Pia, additional, Nguyen, Vy, additional, Marks, Katherine, additional, Nor, Nurhanani Mohamed, additional, Estorninho, Megan, additional, Kronenberg-Versteeg, Deborah, additional, Bingley, Polly J., additional, Todd, John A., additional, Guy, Catherine, additional, Dunger, David B., additional, Powrie, Jake, additional, Willcox, Abby, additional, Foulis, Alan K., additional, Richardson, Sarah J., additional, de Rinaldis, Emanuele, additional, Morgan, Noel G., additional, Lorenc, Anna, additional, and Peakman, Mark, additional

Published
2015
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9. Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

Author

Krogvold, Lars, primary, Edwin, Bjørn, additional, Buanes, Trond, additional, Frisk, Gun, additional, Skog, Oskar, additional, Anagandula, Mahesh, additional, Korsgren, Olle, additional, Undlien, Dag, additional, Eike, Morten C., additional, Richardson, Sarah J., additional, Leete, Pia, additional, Morgan, Noel G., additional, Oikarinen, Sami, additional, Oikarinen, Maarit, additional, Laiho, Jutta E., additional, Hyöty, Heikki, additional, Ludvigsson, Johnny, additional, Hanssen, Kristian F., additional, and Dahl-Jørgensen, Knut, additional

Published
2014
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10. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

Author

Arif, Sefina, primary, Leete, Pia, additional, Nguyen, Vy, additional, Marks, Katherine, additional, Nor, Nurhanani Mohamed, additional, Estorninho, Megan, additional, Kronenberg-Versteeg, Deborah, additional, Bingley, Polly J., additional, Todd, John A., additional, Guy, Catherine, additional, Dunger, David B., additional, Powrie, Jake, additional, Willcox, Abby, additional, Foulis, Alan K., additional, Richardson, Sarah J., additional, de Rinaldis, Emanuele, additional, Morgan, Noel G., additional, Lorenc, Anna, additional, and Peakman, Mark, additional

Published
2014
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11. Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.

Author

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludvigsson J, Hanssen KF, and Dahl-Jørgensen K

Subjects
Adult, Base Sequence, Enterovirus Infections diagnosis, Female, Humans, Male, Molecular Sequence Data, RNA, Viral genetics, Young Adult, Diabetes Mellitus, Type 1 diagnosis, Diabetes Mellitus, Type 1 virology, Enterovirus isolation & purification, Enterovirus Infections virology, Islets of Langerhans virology
Abstract

The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in six adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh-frozen whole pancreatic tissue using PCR and sequencing. Nondiabetic organ donors served as controls. VP1 was detected in the islets of all type 1 diabetic patients (two of nine controls). Hyperexpression of class I HLA molecules was found in the islets of all patients (one of nine controls). Enterovirus-specific RNA sequences were detected in four of six patients (zero of six controls). The results were confirmed in various laboratories. Only 1.7% of the islets contained VP1(+) cells, and the amount of enterovirus RNA was low. The results provide evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, which is consistent with the possibility that a low-grade enteroviral infection in the pancreatic islets contributes to disease progression in humans., (© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.)

Published
2015
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