Search

OBJECTIVE--In diabetes, it remains unclear whether the coronary artery calcium (CAC) score provides additional reformation about total mortality risk beyond traditional risk factors. RESEARCH DESIGN AND METHODS--A total of 1,051 [...]

OBJECTIVE--To assess the additional effect of sudden visceral fat reduction by omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in patients with grade III obesity (G-Ill O) undergoing laparoscopic [...]

OBJECTIVE--To examine sex-specific black/white differences in lipoprotein profile and the role of visceral adiposity and to assess the relationship between insulin sensitivity and lipoprotein profiles in each group. RESEARCH DESIGN [...]

OBJECTIVE--Because of blood lipid concerns, diabetes associations discourage fructose at high intakes. To quantify the effect of fructose on blood lipids in diabetes, we conducted a systematic review and meta-analysis [...]

OBJECTIVE--To test the hypothesis that AIC is associated with subclinical cardiovascular disease (CVD) in a population without evident diabetes, after adjusting for traditional CVD risk factors and BMI. RESEARCH DESIGN [...]

OBJECTIVE--Although cumulative evidence suggests that increased oxidative stress may lead to insulin resistance in vivo or in vitro, community-based studies are scarce. This study examined the longitudinal relationships of oxidative [...]

OBJECTIVE--The purpose of this study was to examine the effects of statin therapy on lipoprotein particle concentrations in patients with the metabolic syndrome. Changes in lipoprorein particle concentration may predict [...]

OBJECTIVE--The aim of this study was to test whether being born small for gestational age (SGA) has an impact on adiponectin and leptin levels and the IGF system in relation [...]

OBJECTIVE--To explore the prevalence of lipid abnormalities and their relationship with albumin excretion and microalbuminuria in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS--The study population comprised 895 young [...]

OBJECTIVE--To assess two physician learning interventions designed to improve safety and quality of diabetes care delivered by primary care physicians (PCPs). RESEARCH DESIGN AND METHODS--This group randomized clinical trial included [...]

OBJECTIVE--To assess coronary heart disease (CHD) risk within levels of the joint distribution of non-HDL and LDL cholesterol among individuals with and without diabetes. RESEARCH DESIGN AND METHODS--We used four [...]

OBJECTIVE--The aim of our study was to examine, in type 2 diabetic patients, the relationship between autoantibodies against oxidatively modified LDL (oxLDL Ab) and two indexes of atherosclerosis, intimal-medial thickness [...]

OBJECTIVE--To evaluate the atherogenicity of lipids in coronary patients with normal fasting glucose (NFG), impaired fasting glucose (IFG), and type 2 diabetes. RESEARCH DESIGN AND METHODS--Serum lipid values, the presence [...]

Glucose-6-phosphatase (G6Pase) is a key enzyme in hepatic glucose metabolism. Altered G6Pase activity in glycogen storage disease and diabetic states is associated with disturbances in lipid metabolism. We studied the effects of acute inhibition of G6Pase activity on hepatic lipid metabolism in nonanesthetized rats. Rats were infused with an inhibitor of the glucose-6-phosphate (G6P) translocator (S4048, 30 mg x [kg.sup.-1] x [h.sup.-1]) for 8 h. Simultaneously, [1-[sup.13]C]acetate was administered for determination of de novo lipogenesis and fractional cholesterol synthesis rates by mass isotopomer distribution analysis. In a separate group of rats, Triton WR 1339 was injected for determination of hepatic VLDL-triglyceride production. S4048 infusion significantly decreased plasma glucose (-11%) and insulin (-48%) levels and increased hepatic G6P (201%) and glycogen (182%) contents. Hepatic triglyceride contents increased from 5.8 ± 1.4 µmol/g liver in controls to 20.6 ± 5.5 µmol/g liver in S4048-treated animals. De novo lipogenesis was increased >10-fold in S4048-treated rats, without changes in cholesterol synthesis rates. Hepatic mRNA levels of acetyl-CoA carboxylase and fatty acid synthase were markedly induced. Plasma triglyceride levels increased fourfold, but no differences in plasma cholesterol levels were seen. Surprisingly, hepatic VLDL-triglyceride secretion was not increased in S4048-treated rats. These studies demonstrate that inhibition of the G6Pase system leads to acute stimulation of fat synthesis and development of hepatic steatosis, without affecting hepatic cholesterol synthesis and VLDL secretion. The results emphasize the strong interactions that exist between hepatic carbohydrate and fat metabolism., Phosphorylation and dephosporylation of glucose by glucokinase and glucose-6-phosphatase (G6Pase), respectively, are key steps in hepatic glucose uptake and release. The balance between the activities of these enzymes represents an [...]

An increase in the incidence of physician-diagnosed diabetes with rosuvastatin in Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) published recently revived clinical [...]

OBJECTIVE--To examine sex and racial/ethnic differences in cardiovascular risk factor treatment and control among individuals with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA). RESEARCH DESIGN AND METHODS--This study was [...]

OBJECTIVE--To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals. RESEARCH DESIGN AND METHODS--The Japan Cholesterol and Diabetes Mellitus Study is [...]

Hyperglycemia closely linked to the development of diabetic vascular complications increases plasma levels of glycated proteins and lipoproteins. Thus, it was the aim of this study to evaluate the effects [...]