1. Use of Nicotinic Acid in the Management of Recurrent Hypoglycemic Episodes in Diabetes
- Author
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Fadil Hannan and Peter Davoren
- Subjects
Advanced and Specialized Nursing ,Type 1 diabetes ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Glucose uptake ,Adipose tissue ,medicine.disease ,Randle cycle ,NEFA ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Lipolysis ,business ,Glycemic - Abstract
Chronic administration of nicotinic acid (NA) has been shown to cause a deterioration in glycemic control in diabetic patients (1,2). Acute use of NA inhibits lipolysis in adipose tissue suppressing circulating nonesterfied fatty acid (NEFA) levels. Once the effect of NA abates, NEFA levels increase above baseline (3). According to the Randle cycle hypothesis, when NEFA availability increases, NEFA oxidation occurs at the expense of glucose oxidation with a resultant reduction in glucose uptake by skeletal muscle and an increase in blood glucose levels (4). Some patients with type 1 diabetes have frequent and often unpredictable hypoglycemic episodes. We hypothesized that the addition of regular oral NA to deliberately …
- Published
- 2001
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