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Microbubbles excited by acoustic fields inside water oscillate and generate acoustic radiation forces and drag-induced acoustic streaming. These forces can be harnessed in various biomedical applications, such as targeted drug delivery and on-chip biomanipulation. The conventional approach for using microbubbles as actuators is to trap them inside microfabricated cavities. Anisotropic forces are applied by constraining the interfaces where the air interacts with water. The existing analytical models derived for spherical bubbles are incapable of predicting the dynamics of bubbles in such configurations. Here, a new model for bubbles entrapped inside arbitrary shaped cavities with multiple circular openings is developed. The semi-analytical model captures a more realistic geometry through a solution to an optimization problem. We challenge the assumption that bubbles should be excited at their first resonance frequency to optimize their performance. The natural frequencies and the correlated normal vibration modes are calculated, which are subsequently used to compute the acoustic streaming patterns and the associated thrust by a finite element simulation. An experimental platform was built to measure the deflection of beams loaded by microfabricated bubble actuators and visualize the generated streaming patterns. The results highlight the contribution of the computational model as a design tool for engineering applications. [ABSTRACT FROM AUTHOR]