1. Waveguide biosensor with integrated detector array for tuberculosis testing.
- Author
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Yan, Rongjin, Lynn, N. Scott, Kingry, Luke C., Yi, Zhangjing, Slayden, Richard A., Dandy, David S., and Lear, Kevin L.
- Subjects
BIOSENSORS ,WAVEGUIDES ,TUBERCULOSIS ,IMMUNOASSAY ,COMPLEMENTARY metal oxide semiconductors ,PROTEINS ,ANTIGENS ,THICK films - Abstract
A label-free immunoassay using a local evanescent array coupled (LEAC) biosensor is reported. Complementary metal oxide semiconductor chips with integrated photoconductor arrays are used to detect an antibody to a M. tuberculosis protein antigen, HspX. The metrology limits of the LEAC sensor using dc and ac measurement systems correspond to average film thicknesses of 28 and 14 pm, respectively. Limits of detection are 87 and 108 pm, respectively, for mouse immunoglobulin G antibody patterning and antigen detection. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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