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One of the most important conditions for obtaining high and high-quality yields of this crop is the timely application of the necessary doses of mineral fertilizers. Therefore, the study of the effectiveness of the use of various brands of mineral fertilizers on winter wheat in the conditions of the Kursk region is an urgent task. In the experiment, the zoned winter wheat variety Lgovskaya-4 was used. Seeding rate - 5 million viable seeds per ha. The plot area is 2000 m2. We studied the effectiveness of the use of 3 brands of mineral fertilizers: NPK (16-16-16), NPK (10-26-26), NPK (8- 20-30). It has been established that the use of mineral fertilizer brand NPK (16-16-16) for presowing cultivation at a dose of N30P30 K30 + ammonium nitrate at a dose of N30 in the tillering phase + ammonium nitrate at a dose of N30 in the booting phase ensured the maximum yield of winter wheat equal to 7,2 t/ha, increased the content of raw gluten in the grain by 3.7%, protein - by 1.3%, starch - by 1.7% compared to the control variant (without fertilization). The use of the same brand of mineral fertilizers was the most economically profitable: the net income amounted to 85,900 rubles/ha, the cost of 1 quintal of grain was 1,304 rubles/ha, and the profitability level was 186%. [ABSTRACT FROM AUTHOR]