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Epidermolysis bullosa (EB) appeared in a patient at the age of 54 years. Other bullous disorders could be excluded by electron microscopy, and there was no family history of EB. The patient would therefore best be classified as having EB acquisita. Repeated direct immunofluorescence studies were, however, negative for all tested serum samples, suggesting that there might be a subgroup lacking immunoglobulin deposits in the skin. Collagen IV, laminin, and fibronectin were expressed normally at the dermoepidermal junction.

The effects of oral zinc sulfate (corresponding to 135 mg of zinc daily) alone and in combination with vitamin A (300,000 international units) daily on acne lesions have been compared with those of vitamin A alone and of a placebo. The number of comedones, papules, pustules, and infiltrates were counted at each visit. After four weeks, there was a significant decrease in the number of papules, pustules, and infiltrates in the zinc-treated groups. The effect of zinc plus vitamin A was not better than zinc alone. After 12 weeks of treatment, the mean acne score had decreased from 100% to 15%. The mechanism for the effect of zinc therapy in acne, to our knowledge, is not presently known.¿

Using histochemical staining techniques, it has been possible to demonstrate the selective uptake of ten different contact allergens by the Langerhans cells. It is postulated that the Langerhans cells form a reticuloepithelial system that clears the epidermis of foreign chemicals. The Langerhans cell is viewed as the site of hapten binding and antigen formation and hence the central target cell in immune contact dermatitis reactions.

Six immunocompromised patients were shown to exhibit Pseudomonas aeruginosa folliculitis in apocrine regions similar to "swimming pool" folliculitis. The lesions evolved within 24 hours as severe ecthyma gangrenosum. The source of the P aeruginosa, serotype O-11, was found in the water system of the hospital. Clinical identification of the lesions and early treatment is important to prevent severe manifestations.