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Your search keyword '"Cella C"' showing total 4 results
Start Over Author "Cella C" Publisher american medical association
4 results on '"Cella C"'

1. Validation of the ONKOTEV Risk Prediction Model for Venous Thromboembolism in Outpatients with Cancer

Author

Cella, C, Knoedler, M, Hall, M, Arcopinto, M, Bagnardi, V, Gervaso, L, Pellicori, S, Spada, F, Zampino, M, Ravenda, P, Frassoni, S, Passaro, A, Milano, M, Laffi, A, Fazio, N, Lordick, F, Cella C. A., Knoedler M., Hall M., Arcopinto M., Bagnardi V., Gervaso L., Pellicori S., Spada F., Zampino M. G., Ravenda P. S., Frassoni S., Passaro A., Milano M., Laffi A., Fazio N., Lordick F., Cella, C, Knoedler, M, Hall, M, Arcopinto, M, Bagnardi, V, Gervaso, L, Pellicori, S, Spada, F, Zampino, M, Ravenda, P, Frassoni, S, Passaro, A, Milano, M, Laffi, A, Fazio, N, Lordick, F, Cella C. A., Knoedler M., Hall M., Arcopinto M., Bagnardi V., Gervaso L., Pellicori S., Spada F., Zampino M. G., Ravenda P. S., Frassoni S., Passaro A., Milano M., Laffi A., Fazio N., and Lordick F.

Abstract

Importance: The assessment of the risk of venous thromboembolism (VTE) among outpatients with cancer represents an unsolved topic. Current international guidelines recommend primary prophylaxis for patients at intermediate to high risk of VTE, indicated by a Khorana score of 2 or more. A previous prospective study developed the ONKOTEV score, a 4-variable risk assessment model (RAM) consisting of a Khorana score of more than 2, metastatic disease, vascular or lymphatic compression, and previous VTE event. Objective: To validate the ONKOTEV score as a novel RAM to assess the risk of VTE among outpatients with cancer. Design, Setting, and Participants: ONKOTEV-2 is a noninterventional prognostic study conducted in 3 European centers located in Italy, Germany, and the United Kingdom among a prospective cohort of 425 ambulatory patients with a histologically confirmed diagnosis of a solid tumor who were receiving active treatments. The total study duration was 52 months, with an accrual period of 28 months (from May 1, 2015, to September 30, 2017) and an overall follow up-period of 24 months (data were censored September 30, 2019). Statistical analysis was performed in October 2019. Exposures: The ONKOTEV score was calculated for each patient at baseline by collecting clinical, laboratory, and imaging data from tests performed for routine practice. Each patient was then observed to detect any thromboembolic event throughout the study period. Main Outcomes and Measures: The primary outcome of the study was the incidence of VTE, including deep vein thrombosis and pulmonary embolism. Results: A total of 425 patients (242 women [56.9%]; median age, 61 years [range, 20-92 years]) were included in the validation cohort of the study. The cumulative incidences for the risk of developing VTE at 6 months were 2.6% (95% CI, 0.7%-6.9%), 9.1% (95% CI, 5.8%-13.2%), 32.3% (95% CI, 21.0%-44.1%), and 19.3% (95% CI, 2.5%-48.0%), respectively, among 425 patients with an ONKOTEV score of 0

Published
2023

2. State Medicaid Coverage for Tobacco-Dependence Treatments--United States, 2006.

Author

Halpin, H. A., McMenamin, S. B., Cella, C. A., Bellows, N. M., and Husten, C. G.

Subjects
CIGARETTE smokers, MEDICAID, NICOTINE addiction treatment, TREATMENT of drug addiction, HEALTH insurance, HUMAN services
Abstract

The article presents a discussion of the types of tobacco-dependence treatments that are covered by Medicaid programs. It is noted that one in 3 adults who receive Medicaid in the U.S. smoke tobacco. The results of a survey conducted by the Center for Health and Public Policy Studies at the University of California, Berkeley in 2006 is summarized. Results showed 39 state Medicaid programs provided coverage for some form of tobacco-dependence treatment. Some Medicaid programs had limitations for these treatments including prior authorization, co-payments and duration of coverage.

Published
2008
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3. State Medicaid Coverage for Tobacco-Dependence Treatments--United States, 2005.

Author

Halpin, H. A., McMenamin, S. B., Cella, C. A., Husten, C. C., and Rosenthal, Abby

Subjects
MEDICAID, NICOTINE addiction treatment, MEDICAID beneficiaries, HEALTH insurance, MEDICAL care of poor people, HEALTH policy, SUBSTANCE abuse treatment
Abstract

The article summarizes and explores the results of a 2005 survey conducted among all states in the U.S. regarding the types of Medicaid coverage provided for the treatment of tobacco dependence since 1994. Findings included that 38 state programs provided coverage for some form of treatment for all recipients, four provided coverage only to women who were pregnant, and Oregon provided full coverage for all recommended treatments articulated in the 2000 Public Health Service guideline. Methods used to conduct the survey and possible limitations to report findings are presented.

Published
2006
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4. Validation of the ONKOTEV Risk Prediction Model for Venous Thromboembolism in Outpatients with Cancer

Author

Chiara A. Cella, Maren Knoedler, Marcia Hall, Michele Arcopinto, Vincenzo Bagnardi, Lorenzo Gervaso, Stefania Pellicori, Francesca Spada, Maria G. Zampino, Paola S. Ravenda, Samuele Frassoni, Antonio Passaro, Monica Milano, Alice Laffi, Nicola Fazio, Florian Lordick, Cella, C, Knoedler, M, Hall, M, Arcopinto, M, Bagnardi, V, Gervaso, L, Pellicori, S, Spada, F, Zampino, M, Ravenda, P, Frassoni, S, Passaro, A, Milano, M, Laffi, A, Fazio, N, and Lordick, F

Subjects
Risk Prediction Model, General Medicine, Venous Thromboembolism
Abstract

ImportanceThe assessment of the risk of venous thromboembolism (VTE) among outpatients with cancer represents an unsolved topic. Current international guidelines recommend primary prophylaxis for patients at intermediate to high risk of VTE, indicated by a Khorana score of 2 or more. A previous prospective study developed the ONKOTEV score, a 4-variable risk assessment model (RAM) consisting of a Khorana score of more than 2, metastatic disease, vascular or lymphatic compression, and previous VTE event.ObjectiveTo validate the ONKOTEV score as a novel RAM to assess the risk of VTE among outpatients with cancer.Design, Setting, and ParticipantsONKOTEV-2 is a noninterventional prognostic study conducted in 3 European centers located in Italy, Germany, and the United Kingdom among a prospective cohort of 425 ambulatory patients with a histologically confirmed diagnosis of a solid tumor who were receiving active treatments. The total study duration was 52 months, with an accrual period of 28 months (from May 1, 2015, to September 30, 2017) and an overall follow up-period of 24 months (data were censored September 30, 2019). Statistical analysis was performed in October 2019.ExposuresThe ONKOTEV score was calculated for each patient at baseline by collecting clinical, laboratory, and imaging data from tests performed for routine practice. Each patient was then observed to detect any thromboembolic event throughout the study period.Main Outcomes and MeasuresThe primary outcome of the study was the incidence of VTE, including deep vein thrombosis and pulmonary embolism.ResultsA total of 425 patients (242 women [56.9%]; median age, 61 years [range, 20-92 years]) were included in the validation cohort of the study. The cumulative incidences for the risk of developing VTE at 6 months were 2.6% (95% CI, 0.7%-6.9%), 9.1% (95% CI, 5.8%-13.2%), 32.3% (95% CI, 21.0%-44.1%), and 19.3% (95% CI, 2.5%-48.0%), respectively, among 425 patients with an ONKOTEV score of 0, 1, 2, and greater than 2 (P Conclusions and RelevanceThis study suggests that, because the ONKOTEV score has been validated in this independent study population as a novel predictive RAM for cancer-associated thrombosis, it can be adopted into practice and into clinical interventional trials as a decision-making tool for primary prophylaxis.

Published
2023

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