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1. Effect of Adenosine-Regulating Agent Acadesine on Morbidity and Mortality Associated With Coronary Artery Bypass Grafting The RED-CABG Randomized Controlled Trial.

Author

Newman, Mark F., Ferguson, T. Bruce, White, Jennifer A., Ambrosio, Giuseppe, Koglin, Joerg, Nussmeier, Nancy A., Pearl, Ronald G., Pitt, Bertram, Wechsler, Andrew S., Weisel, Richard D., Reece, Tammy L., Lira, Armando, and Harrington, Robert A.

Subjects
*5-Aminoimidazole-4-carboxamide riboside, *ADENOSINES, *DISEASES, *MORTALITY, *CORONARY artery bypass, *LEFT heart ventricle, *CARDIOTONIC agents, *CLINICAL trials
Abstract

The article presents information on the effects of the acadesine, an adenosine-regulating agent on the morbidity and mortality associated with the coronary artery bypass grafting (CABG), which could be high in the patients with poor left ventricular function. It informs that the several drugs with purported cardioprotective effects including sodium-proton exchange inhibitor, a complement activation inhibitor and a purinergic receptor antagonist failed during the randomized control trials in the patients undergoing the CABG surgery. It further informs that there is a requirement of a fully functional therapy for this.

Published
2012
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