It is generally known that patient prognosis and cardiac function are related to the amount of the left ventricle (LV) infarcted; thus, reliable clinical methods that are able to estimate the extent of both acute and remote myocardial necrosis are needed. Additionally, the recent interest in the limitation of acute myocardial infarct (MI) size with therapeutic interventions has prompted the evaluation of many clinical methods aimed at estimating the size of an acute MI. For more than 50 years, the 12-lead electrocardiogram (ECG) has remained the standard for determining the presence and location of MIs. Because it is universally available, noninvasive, inexpensive, and easily repeatable, it is important to know the extent to which the ECG could be implemented in the estimation of MI size. The quantitative Selvester QRS scoring system, which was designed from computer simulations, utilizes the information on the ECG to estimate MI size. The purposes of