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My purpose in this paper is to stress' and reemphasize the danger of using calcium gluconate for intramuscular injection in infants. In 1936 there were two reports which recorded the effects of calcium deposition in the tissues of 2 infants who had received the calcium intramuscularly. Tumpeer's case 1 was that of an infant who weighed 6 pounds 13 ounces (3.1 Kg.) and received 9 cc. of 10 per cent calcium gluconate intramuscularly on the third day of life. At the age of 5 weeks x-ray examination demonstrated a radiopaque substance in the thigh and buttocks where the injection had been made. A week later there was a slough of the tissue, with the extrusion of calcified material which was identified as calcium phosphate. By the fourth month of life an x-ray of the region was normal. Von Hofe 2 reported the case of an infant who had received