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The second volume of this overdue series continues to follow the high standards of Volume 1. The publication begins with a review of the status and recent advancements made by pharmacology in India, China, and Europe. The remainder of the volume reviews in detail major advances made in various sections of pharmacology. The 2 general areas of pharmacology, biochemical and physiological, seem to be well balanced. This balanced presentation is evidenced by the following topics: biochemical mechanism, drug absorption and excretion, comparative pharmacology, chemotherapy, hormones, central nervous system, cardiorenal, anesthesia, toxicology, and advances in biochemical assay techniques. This volume is highly recommended for the physician in practice or research. Reviews of this type offer an excellent opportunity to keep abreast with this rapidly developing basic science.

SUMMARY. The inoculation treatment of vulvovaginitis apparently shortens the stay of patients in hospital. Whether or not it actually lessens the total duration of the disease, as compared with other methods of treatment, future investigations must determine. Old strains are more effective than fresh ones. It is desirable, though apparently not absolutely necessary, to take the index while pursuing the treatment. There is no correspondence between the index and the vaginal discharge. Our thanks are due to our colleagues on the staff of Cook County Hospital, who kindly allowed us to inoculate their patients, and to the Visiting Nurses' Association for their help in tracing patients. We also are under special obligation to Dr. Hektoen and Dr. Hamilton for much valuable help and suggestion in the opsonic work. 439 North State Street. 26 Junior Terrace. A clinical experience of ten years with institution epidemics of gonorrhea, occurring at not infrequent

Among the bacterial infections in which local antiseptic treatment does not always prove satisfactory, gonorrheal vulvovaginitis may be well included. It appears clear that whatever organisms are on the surface of the mucosa in such an infection will be disposed of, in great part at least, by the action of antiseptics, but those at a deeper level will be inaccessible to their action. Many such organisms so located may be taken care of by being washed to the surface by lymph. A great task, however, will still remain for the body to accomplish, namely: Destruction of gonococci beyond the reach of local medication through its immunizing mechanism. As the immunizing apparatus is ordinarily slow in effecting this, we attempted to call on it in a number of cases for increased labor through the stimulus of vaccine therapy, withholding at the same time all other treatment, and we present below our