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The present study deals with the effect of feeding diets containing various concentrations of whole meat on the amount of urea in the urine and blood and the urea (Addis) ratio, urea excreted/blood urea in partially nephrectomized, unilaterally nephrectomized and intact rats. The experimental procedure, the experimental diets and abbreviations were outlined in a previous paper. 1 The data for all animals excreting less than 50 per cent of the urea solution administered were excluded. The previous data have been supplemented by values obtained at frequent intervals in individual animals. RESULTS The effect of various concentrations of whole dried meat on the amount of urea in the blood and urine and on the urea ratio, urea excreted per hour X 100, of partially nephrectomized and control aniurea in 100 cc. blood mals (unilaterally nephrectomized and intact) is shown in chart 1. Five phases of renal function are

This is the first of a short series of papers, the outcome of an attempt to draw quantitative structural deductions from functional results. The few methods used are discussed and criticized only in reference to the question as to whether the results give information in regard to the amount of secreting tissue in the kidney. This narrow point of view has been adopted because the purpose of the inquiry is entirely utilitarian and clinical. All manifestations of renal function have an intrinsic interest from the standpoint of physiology, but it is maintained that only those from which we can draw quantitative conclusions about the amount of tissue in the kidney are of immediate and practical clinical importance. Such an idea is foreign to nearly all the recent work on this subject. Nevertheless, from the time of Bright up to about the beginning of the last decade, the hope that functional

Many attempts have been made in recent years to develop a satisfactory test for the urea function of the kidney. Ambard presented his coefficient of urea excretion and F. C. McLean introduced the McLean index, which utilized the principles of Ambard's formula but simplified them. H. MacLean and de Wesselow1brought out the urea concentration test. Addis2studied the ratio between the one hour urine urea and the urea in 100 cc. of blood and Rabinowitz employed the urea concentration factorVarious investigators have shown that urea excretion in normal persons depends on the blood urea concentration as well as on the renal efficiency and also that the concentration of urea in the urine in normal persons can be increased indefinitely, under conditions compatible with life, by increasing the blood urea concentration. It has been further proved that the volume of water excreted has only a slight effect on urea excretion