1. Signaling Delays Preclude Defects in Lateral Inhibition Patterning.
- Author
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Glass, David S., Xiaofan Jin, and Riedel-Kruse, Ingmar H.
- Subjects
- *
CELLULAR signal transduction , *BIOCHEMISTRY , *DEVELOPMENTAL cytology - Abstract
Lateral inhibition represents a well-studied example of biology's ability to self-organize multicellular spatial patterns with single-cell precision. Despite established biochemical mechanisms for lateral inhibition (e.g., Delta-Notch), it remains unclear how cell-cell signaling delays inherent to these mechanisms affect patterning outcomes. We investigate a compact model of lateral inhibition highlighting these delays and find, remarkably, that long delays can ensure defect-free patterning. This effect is underscored by an interplay with synchronous oscillations, cis interactions, and signaling strength. Our results suggest that signaling delays, though previously posited as a source of developmental defects, may in fact be a general regulatory knob for tuning developmental robustness. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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