1. Paraquat herbicide diminishes chemoreflex sensitivity, induces cardiac autonomic imbalance and impair cardiac function in rats
- Author
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Fernando C. Ortiz, Esteban Díaz-Jara, David C. Andrade, Angélica P. Ríos-Gallardo, Karla G. Schwarz, Katherin V. Pereyra, Rodrigo R. del Río, Domiziana Ortolani, Sussy S. Bastías, and Camilo Toledo
- Subjects
Male ,Paraquat ,inorganic chemicals ,Cardiac function curve ,medicine.medical_specialty ,Physiology ,Autonomic Nervous System ,Ventricular Function, Left ,Autonomic control ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Heart Rate ,Physiology (medical) ,Internal medicine ,Reflex ,medicine ,Animals ,heterocyclic compounds ,Lung ,Exercise Tolerance ,Ventricular Remodeling ,Herbicides ,business.industry ,Arrhythmias, Cardiac ,Heart ,Chemoreceptor Cells ,chemistry ,Autonomic imbalance ,Breathing ,Cardiology ,Hypertrophy, Left Ventricular ,Pulmonary Ventilation ,Cardiology and Cardiovascular Medicine ,business - Abstract
Paraquat herbicide is still employed in agricultural practices in several countries. Here, we showed for the first time that 1 mo paraquat administration results in cardiac adverse remodeling, blunts ventilatory chemoreflex drive, and promotes irregular breathing at rest in previously healthy rats. In addition, paraquat exposure induced cardiac autonomic imbalance and cardiac electrophysiology alterations. Lastly, cardiac diastolic dysfunction was overt in rats following 1 mo of paraquat treatment.
- Published
- 2021
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