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Your search keyword '"Khosla, M."' showing total 11 results
Start Over Author "Khosla, M." Publisher american physiological society
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11. Vascular and adrenocortical responses to a specific antagonist of angiotensin II.

Author

Bravo EL, Khosla MC, and Bumpus FM

Subjects
Adrenal Glands blood supply, Aldosterone metabolism, Angiotensin II analogs & derivatives, Angiotensin II antagonists & inhibitors, Animals, Blood Pressure drug effects, Dexamethasone pharmacology, Dogs, Hydrocortisone metabolism, Kidney physiology, Male, Nephrectomy, Potassium blood, Regional Blood Flow, Sodium blood, Adrenal Cortex metabolism, Adrenal Glands metabolism, Angiotensin II metabolism, Chemoreceptor Cells, Vasomotor System metabolism
Abstract

Angiotensin II receptors in vascular smooth muscle and adrenal cortex have been characterized in the dog. The evidence was derived chiefly from experiments that assessed the ability of a structural analog of angiotensin II, [Sar1, Ile8] AII, to antagonize the effects of exogenously administered angiotensin II on arterial pressure and aldosterone secretion. [Sar1, Ile8] AII is a potent and specific blocker of the pressor response to angiotensinII; in the adrenal cortex, it is a much less effective inhibitor of aldosterone biosynthesis. These results indicate differences in the receptor sites for angiotensin II in vascular smooth muscle and adrenal cortex. Further, they raise the possibility that angiotensin II stimulates aldosterone secretion by mechanisms other than have already been proposed.

Published
1975
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