1. Exercise physiology of the left atrium: quantity and timing of contribution to cardiac output
- Author
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Dai-Yin Lu, Dwight Bibby, Nelson B. Schiller, Qizhi Fang, Anish Bhatt, and Laura Flink
- Subjects
Adult ,Male ,Cardiac output ,medicine.medical_specialty ,Physiology ,Left atrium ,Blood Pressure ,Disease ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Physiology (medical) ,Internal medicine ,Humans ,Medicine ,Exercise physiology ,Exercise ,business.industry ,Stroke Volume ,Middle Aged ,Atrial Function ,medicine.anatomical_structure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Diseases of the left atrium (LA) are major sources of disability (e.g., strokes and fatigue), but its exercise physiology has been unstudied. Such knowledge may allow early recognition of disease and suggest therapies. We show that in normal subjects, low-level exercise decreases LA volume and increases its ejection fraction. However, these changes offset each other volumetrically, and the contribution to LV filling from a full to an empty LA (reservoir function) is static. Higher levels of exercise do not change LA reservoir contribution. Blood flowing directly from the pulmonary vein to LV (conduit flow) impelled by augmented LV active relaxation (suction) is the major source of a modest increase in LV stroke volume. The major source of increased cardiac output with exercise is heart rate. During all stages of exercise, the LA works hard but only to keep up. We believe that our findings provide an additional set of benchmarks through which to quantitate LA pathology and gauge its progression.
- Published
- 2021