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The effects of cholecystokinin (CCK) on the activity of the neurons of the area postrema (AP) were analyzed in rat brain slices via in vitro electrophysiological single-unit recording techniques. Administration of multiple doses of CCK in rat brain slices elicited activated AP neurons in a dose-dependent manner. The excitatory effects of CCK in the AP neurons were also mediated by CCKB receptors indicating the role of AP in initiating appropriate responses in the central nervous system for the regulation of circulating concentrations of CCK.

The inhibitory effect of arginine vasopressin (AVP) is due to interconnections with area postrema (AP) neurons activated by the peptide. AP, a circumventricular organ present on the dorsal surface of the medulla is essential for cardiovascular regulation. Insertion of slices with aCSF containing V1 antagonist inhibit the excitatory responses of five AP cells to AVP indicating that influence of AVP on AP neurons is a V1 receptor-mediated excitatory action.