10 results on '"Visniauskas, Bruna"'
Search Results
2. Differences and the impact of G protein-coupled estrogen receptor deletion in the vascular and renal response to aldosterone
- Author
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Leite, Ana Paula, primary, Ogola, Ben, additional, Visniauskas, Bruna, additional, Kilanowski-Doroh, Isabella, additional, Horton, Alec, additional, Diaz, Zaidmara, additional, and Lindsey, Sarah, additional
- Published
- 2023
- Full Text
- View/download PDF
3. High plasma soluble prorenin receptor (sPRR) is associated with vascular damage in male but not female mice fed a high fat diet
- Author
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Visniauskas, Bruna, primary, Reverte, Virginia, additional, Abshire, Caleb M., additional, Ogola, Benard O., additional, Rosales, Carla B., additional, Galeas-Pena, Michelle, additional, Sure, Venkata N., additional, Sakamuri, Siva S.V.P., additional, Harris, Nicholas R., additional, Kilanowski-Doroh, Isabella, additional, McNally, Alexandra B., additional, Horton, Alec C., additional, Zimmerman, Margaret, additional, Katakam, Prasad V. G., additional, Lindsey, Sarah H., additional, and Prieto, Minolfa C., additional
- Published
- 2023
- Full Text
- View/download PDF
4. Sex differences in vascular aging and impact of GPER deletion
- Author
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Ogola, Benard O., primary, Abshire, Caleb M., additional, Visniauskas, Bruna, additional, Kiley, Jasmine X., additional, Horton, Alec C., additional, Clark-Patterson, Gabrielle L., additional, Kilanowski-Doroh, Isabella, additional, Diaz, Zaidmara, additional, Bicego, Anne N., additional, McNally, Alexandra B., additional, Zimmerman, Margaret A., additional, Groban, Leanne, additional, Trask, Aaron J., additional, Miller, Kristin S., additional, and Lindsey, Sarah H., additional
- Published
- 2022
- Full Text
- View/download PDF
5. High-plasma soluble prorenin receptor is associated with vascular damage in male, but not female, mice fed a high-fat diet.
- Author
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Visniauskas, Bruna, Reverte, Virginia, Abshire, Caleb M., Ogola, Benard O., Rosales, Carla B., Galeas-Pena, Michelle, Sure, Venkata N., Sakamuri, Siva S. V. P., Harris, Nicholas R., Kilanowski-Doroh, Isabella, Mcnally, Alexandra B., Horton, Alec C., Zimmerman, Margaret, Katakam, Prasad V. G., Lindsey, Sarah H., and Prieto, Minolfa C.
- Subjects
- *
PRORENIN receptor , *HIGH-fat diet , *SYSTOLIC blood pressure , *TYPE 2 diabetes , *RENIN-angiotensin system - Abstract
Plasma soluble prorenin receptor (sPRR) displays sexual dimorphism and is higher in women with type 2 diabetes mellitus (T2DM). However, the contribution of plasma sPRR to the development of vascular complications in T2DM remains unclear. We investigated if plasma sPRR contributes to sex differences in the activation of the systemic renin-angiotensin-aldosterone system (RAAS) and vascular damage in a model of high-fat diet (HFD)-induced T2DM. Male and female C57BL/6J mice were fed either a normal fat diet (NFD) or an HFD for 28 wk to assess changes in blood pressure, cardiometabolic phenotype, plasma prorenin/renin, sPRR, and ANG II. After completing dietary protocols, tissues were collected from males to assess vascular reactivity and aortic reactive oxygen species (ROS). A cohort of male mice was used to determine the direct contribution of increased systemic sPRR by infusion. To investigate the role of ovarian hormones, ovariectomy (OVX) was performed at 32 wk in females fed either an NFD or HFD. Significant sex differences were found after 28 wk of HFD, where only males developed T2DM and increased plasma prorenin/renin, sPRR, and ANG II. T2DM in males was accompanied by nondipping hypertension, carotid artery stiffening, and aortic ROS. sPRR infusion in males induced vascular thickening instead of material stiffening caused by HFD-induced T2DM. While intact females were less prone to T2DM, OVX increased plasma prorenin/renin, sPRR, and systolic blood pressure. These data suggest that sPRR is a novel indicator of systemic RAAS activation and reflects the onset of vascular complications during T2DM regulated by sex. NEW & NOTEWORTHY High-fat diet (HFD) for 28 wk leads to type 2 diabetes mellitus (T2DM) phenotype, concomitant with increased plasma soluble prorenin receptor (sPRR), nondipping blood pressure, and vascular stiffness in male mice. HFD-fed female mice exhibiting a preserved cardiometabolic phenotype until ovariectomy revealed increased plasma sPRR and blood pressure. Plasma sPRR may indicate the status of systemic renin-angiotensin-aldosterone system (RAAS) activation and the onset of vascular complications during T2DM in a sex-dependent manner. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism
- Author
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Morais, Rafael L., primary, Hilzendeger, Aline M., additional, Visniauskas, Bruna, additional, Todiras, Mihail, additional, Alenina, Natalia, additional, Mori, Marcelo A., additional, Araújo, Ronaldo C., additional, Nakaie, Clovis R., additional, Chagas, Jair R., additional, Carmona, Adriana K., additional, Bader, Michael, additional, and Pesquero, João B., additional
- Published
- 2017
- Full Text
- View/download PDF
7. High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism.
- Author
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Morais, Rafael L., Hilzendeger, Aline M., Visniauskas, Bruna, Todiras, Mihail, Alenina, Natalia, Mori, Marcelo A., Araújo, Ronaldo C., Nakaie, Clovis R., Chagas, Jair R., Carmona, Adriana K., Bader, Michael, and Pesquero, João B.
- Subjects
AMINOPEPTIDASES ,BLOOD pressure ,OBESITY - Abstract
Obesity is assumed to be a major cause of human essential hypertension; however, the mechanisms responsible for weight-related increase in blood pressure (BP) are not fully understood. The prevalence of hypertension induced by obesity has grown over the years, and the role of the renin-angiotensin-aldosterone system (RAAS) in this process continues to be elucidated. In this scenario, the ob/ob mice are a genetic obesity model generally used for metabolic disorder studies. These mice are normotensive even though they present several metabolic conditions that predispose them to hypertension. Although the normotensive trait in these mice is associated with the poor activation of sympathetic nervous system by the lack of leptin, we demonstrated that ob/ob mice present massively increased aminopeptidase A (APA) activity in the circulation. APA enzyme metabolizes angiotensin (ANG) II into ANG III, a peptide associated with intrarenal angiotensin type 2 (AT2) receptor activation and induction of natriuresis. In these mice, we found increased ANG-III levels in the circulation, high AT2 receptor expression in the kidney, and enhanced natriuresis. AT2 receptor blocking and APA inhibition increased BP, suggesting the ANG III-AT2 receptor axis as a complementary BP control mechanism. Circulating APA activity was significantly reduced by weight loss independently of leptin, indicating the role of fat tissue in APA production. Therefore, in this study we provide new data supporting the role of APA in BP control in ob/ob mouse strain. These findings improve our comprehension about obesity-related hypertension and suggest new tools for its treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
8. Hypertension disrupts the vascular clock in both sexes.
- Author
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Visniauskas B, Ogola BO, Kilanowski-Doroh I, Harris NR, Diaz ZT, Horton AC, Blessinger SA, McNally AB, Zimmerman MA, Arnold AC, and Lindsey SH
- Abstract
Blood pressure (BP) displays a circadian rhythm and disruptions in this pattern elevate cardiovascular risk. While both central and peripheral clock genes are implicated in these processes, the importance of vascular clock genes is not fully understood. BP, vascular reactivity, and the renin-angiotensin-aldosterone system display overt sex differences, but whether changes in circadian patterns underlie these differences is unknown. Therefore, we hypothesized that circadian rhythms and vascular clock genes would differ across sex and would be blunted by Ang II-induced hypertension. Ang II infusion elevated BP and disrupted circadian patterns similarly in both males and females. In females, an impact on heart rate and locomotor activity was revealed, while in males hypertension suppressed baroreflex sensitivity. A marked disruption in the vascular expression patterns of Per1 and Bmal1 were noted in both sexes. Vascular expression of the G protein-coupled estrogen receptor ( Gper1 ) also showed diurnal synchronization in both sexes that was similar to that of Per1 and Per2 and disrupted by hypertension. In contrast, vascular expression of Esr1 showed a diurnal rhythm and hypertension-induced disruption only in females. This study shows a strikingly similar impact of hypertension on BP rhythmicity, vascular clock genes, and vascular estrogen receptor expression in both sexes. We identified a greater impact of hypertension on locomotor activity and heart rate in females and on baroreflex sensitivity in males and also revealed a diurnal regulation of vascular estrogen receptors. These insights highlight the intricate ties between circadian biology, sex differences, and cardiovascular regulation.
- Published
- 2024
- Full Text
- View/download PDF
9. Sex differences in vascular aging and impact of GPER deletion.
- Author
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Ogola BO, Abshire CM, Visniauskas B, Kiley JX, Horton AC, Clark-Patterson GL, Kilanowski-Doroh I, Diaz Z, Bicego AN, McNally AB, Zimmerman MA, Groban L, Trask AJ, Miller KS, and Lindsey SH
- Subjects
- Animals, Blood Pressure physiology, Carotid Arteries diagnostic imaging, Female, Male, Mice, Receptors, G-Protein-Coupled genetics, Sex Characteristics, Pulse Wave Analysis, Vascular Stiffness physiology
- Abstract
Aging is a nonmodifiable risk factor for cardiovascular disease associated with arterial stiffening and endothelial dysfunction. We hypothesized that sex differences exist in vascular aging processes and would be attenuated by global deletion of the G protein-coupled estrogen receptor. Blood pressure was measured by tail-cuff plethysmography, pulse wave velocity (PWV) and echocardiography were assessed with high-resolution ultrasound, and small vessel reactivity was measured using wire myography in adult (25 wk) and middle-aged (57 wk) male and female mice. Adult female mice displayed lower blood pressure and PWV, but this sex difference was absent in middle-aged mice. Aging significantly increased PWV but not blood pressure in both sexes. Adult female carotids were more distensible than males, but this sex difference was lost during aging. Acetylcholine-induced relaxation was greater in female than male mice at both ages, and only males showed aging-induced changes in cardiac hypertrophy and function. GPER deletion removed the sex difference in PWV and ex vivo stiffness in adult mice. The sex difference in blood pressure was absent in KO mice and was associated with endothelial dysfunction in females. These findings indicate that the impact of aging on arterial stiffening and endothelial function is not the same in male and female mice. Moreover, nongenomic estrogen signaling through GPER impacted vascular phenotype differently in male and female mice. Delineating sex differences in vascular changes during healthy aging is an important first step in improving early detection and sex-specific treatments in our aging population. NEW & NOTEWORTHY Indices of vascular aging were different in male and female mice. Sex differences in pulse wave velocity, blood pressure, and large artery stiffness were abrogated in middle-aged mice, but the female advantage in resistance artery vasodilator function was maintained. GPER deletion abrogated these sex differences and significantly reduced endothelial function in adult female mice. Additional studies are needed to characterize sex differences in vascular aging to personalize early detection and treatment for vascular diseases.
- Published
- 2022
- Full Text
- View/download PDF
10. High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT 2 receptor-dependent mechanism.
- Author
-
Morais RL, Hilzendeger AM, Visniauskas B, Todiras M, Alenina N, Mori MA, Araújo RC, Nakaie CR, Chagas JR, Carmona AK, Bader M, and Pesquero JB
- Subjects
- Angiotensin II Type 1 Receptor Blockers pharmacology, Angiotensins blood, Animals, Caloric Restriction, Cyclic GMP metabolism, Diet, High-Fat, Enzyme Inhibitors pharmacology, Glutamyl Aminopeptidase antagonists & inhibitors, Glutamyl Aminopeptidase blood, Kidney enzymology, Leptin pharmacology, Male, Mice, Mice, Inbred C57BL, Sodium urine, Blood Pressure, Glutamyl Aminopeptidase metabolism, Obesity physiopathology, Receptor, Angiotensin, Type 2 metabolism
- Abstract
Obesity is assumed to be a major cause of human essential hypertension; however, the mechanisms responsible for weight-related increase in blood pressure (BP) are not fully understood. The prevalence of hypertension induced by obesity has grown over the years, and the role of the renin-angiotensin-aldosterone system (RAAS) in this process continues to be elucidated. In this scenario, the ob/ob mice are a genetic obesity model generally used for metabolic disorder studies. These mice are normotensive even though they present several metabolic conditions that predispose them to hypertension. Although the normotensive trait in these mice is associated with the poor activation of sympathetic nervous system by the lack of leptin, we demonstrated that ob/ob mice present massively increased aminopeptidase A (APA) activity in the circulation. APA enzyme metabolizes angiotensin (ANG) II into ANG III, a peptide associated with intrarenal angiotensin type 2 (AT
2 ) receptor activation and induction of natriuresis. In these mice, we found increased ANG-III levels in the circulation, high AT2 receptor expression in the kidney, and enhanced natriuresis. AT2 receptor blocking and APA inhibition increased BP, suggesting the ANG III-AT2 receptor axis as a complementary BP control mechanism. Circulating APA activity was significantly reduced by weight loss independently of leptin, indicating the role of fat tissue in APA production. Therefore, in this study we provide new data supporting the role of APA in BP control in ob/ob mouse strain. These findings improve our comprehension about obesity-related hypertension and suggest new tools for its treatment. NEW & NOTEWORTHY In this study, we reported an increased angiotensin III generation in the circulation of ob/ob mice caused by a high aminopeptidase A activity. These findings are associated with an increased natriuresis found in these mice and support the role of renin-angiotensin-aldosterone system as additional mechanism regulating blood pressure in this genetic obese strain., (Copyright © 2017 the American Physiological Society.)- Published
- 2017
- Full Text
- View/download PDF
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