1. Single photon emission computed tomography (SPECT) with [123I]IMP in the differential diagnosis of psychiatric disorders.
- Author
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O'Connell RA, Van Heertum RL, Billick SB, Holt AR, Gonzalez A, Notardonato H, Luck D, and King LN
- Subjects
- AIDS Dementia Complex diagnostic imaging, AIDS Dementia Complex psychology, Adult, Alzheimer Disease diagnostic imaging, Alzheimer Disease psychology, Amphetamines, Bipolar Disorder diagnostic imaging, Bipolar Disorder psychology, Brain Mapping, Caudate Nucleus blood supply, Cerebral Cortex blood supply, Depressive Disorder diagnostic imaging, Depressive Disorder psychology, Diagnosis, Differential, Female, Humans, Iodine Radioisotopes, Iofetamine, Male, Middle Aged, Neurocognitive Disorders psychology, Psychotic Disorders diagnostic imaging, Psychotic Disorders psychology, Regional Blood Flow physiology, Schizophrenia diagnostic imaging, Schizophrenic Psychology, Brain blood supply, Neurocognitive Disorders diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Abstract
Single photon emission computed tomography (SPECT) with [123I]N-isopropyl iodoamphetamine--[123I]IMP--was used to study regional cerebral blood flow (rCBF) in 94 psychiatric patients and six controls. Patients with dementias had distinct brain-image patterns, consistent with the expected neuropathology. Major depressives had decreased cortical and subcortical rCBF. Increased caudate rCBF was observed in schizophrenics and other psychoses with positive symptoms. SPECT is a practical method of functional brain imaging with potential in the differential diagnosis of neuropsychiatric disorders. Further studies are needed to assess the effect of other variables on brain-image patterns.
- Published
- 1989
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