1. Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury.
- Author
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Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, and Mori S
- Subjects
- Adult, Anisotropy, Female, Follow-Up Studies, Glasgow Coma Scale, Humans, Image Processing, Computer-Assisted, Linear Models, Male, Middle Aged, Psychiatric Status Rating Scales, Young Adult, Brain pathology, Brain Injuries complications, Depressive Disorder, Major diagnosis, Depressive Disorder, Major etiology, Diffusion Tensor Imaging
- Abstract
There are currently no known early neuroanatomical markers predictive of the development of major depression or depressive symptoms after mild traumatic brain injury (mTBI). The authors conducted a 1-year longitudinal pilot study to determine whether diffusion tensor imaging (DTI) measures collected within 1 month of mTBI could predict incident depression. Of the 14 subjects who met study inclusion criteria, 4 (28.6%) developed major depression over the follow-up period. Compared with the nondepressed group, those who developed depression had white-matter abnormalities in the fronto-temporal regions measured by DTI. These preliminary results highlight the need for additional studies, including studies using a larger sample and appropriate controls.
- Published
- 2012
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