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The article discusses the regulation of psychedelics in the United States beyond the Controlled Substances Act, presenting a three-dimensional framework for characterizing policy options. It highlights the varying degrees of liberalization in psychedelic regulations at the city and state levels, emphasizing the need for guidance on non-medicalized uses and risk reduction practices. The framework categorizes psychedelic uses based on legality, therapeutic intention, and structure, providing a nuanced approach to analyzing and comparing different policy options. The article also reviews current non-federally regulated policy options to illustrate how the framework can be applied in practice. [Extracted from the article]