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This article briefly outlines a program of research aimed at creating culturally and contextually relevant alcohol use early interventions for First Nations adolescents. We created a collaborative relationship with communities aimed at adapting established intervention approaches for use with First Nations adolescents. Employing a 4-stage method (see Mushquash, Comeau, McLeod, and Stewart, 2010), we tested Cooper's (1994) motivational model of alcohol use (see Mushquash, Stewart, Comeau, & McGrath, 2008), personality-motive relationships (see Mushquash, Stewart, Mushquash, Comeau, & McGrath, 2013), and delivered a tailored, matched intervention (see Mushquash, Comeau, & Stewart, 2007). We found that this approach resulted in reductions in frequency of drinking, heavy episodic (i.e., binge) drinking, and negative alcohol-related consequences. This approach is one way in which researchers might collaborate with First Nation communities to develop interventions to address community-based priorities.Keywords: First Nation, brief intervention, personality, alcohol use motivesResumeCet article presente sommairement un programme de recherche dont l'objectif est d'etablir des interventions pour enrayer la consommation precoce d'alcool, qui sont adaptees a la culture et au contexte des adolescents des Premieres Nations. Les auteurs ont etabli une relation de collaboration avec les communautes afin d'adapter des approches d'intervention existantes destinees aux adolescents de Premieres Nations. Ils ont utilise une methode en quatre temps (voir Mushquash, Comeau, McLeod & Stewart, 2010) pour tester le modele motivationnel de consommation d'alcool de Cooper (1994; voir Mushquash, Stewart, Comeau & McGrath, 2008) et les relations personnalite - motivation ( voir Mushquash, Stewart, Mushquash, Comeau & McGrath, 2013), pour ensuite concevoir des interventions sur mesure correspondantes (voir Mushquash, Comeau & Stewart, 2007). Selon les auteurs, cette approche a permis de reduire la frequence de la consommation, des beuveries express et des consequences negatives associees a l'alcool. Elle constitue une facon dont les chercheurs pourraient collaborer avec les communautes des Premieres Nations en vue d'etablir des interventions qui correspondent aux priorites de ces dernieres.Mots-cles : Premiere Nation, breve intervention, personnalite, con- sommation d'alcool, motifs.Research suggests there are high levels of mental health problems (Kirmayer, Brass, & Tait, 2000) and substance use (Chansonneuve, 2007) among Aboriginal peoples in Canada. Our understandings of mental health and substance use among First Nations people must recognise diversity and resist pressures to conceptualise all First Nations people as a homogenous group. While many First Nations may share similar histories (e.g., colo- nialism) and current contexts (e.g., poverty), recognising and hon- ouring diversity is of great importance. To understand mental health and substance use among First Nations peoples, mixed- methods approaches that are collaborative and emphasise respect for community-based knowledge and the importance of relation- ships are needed.Throughout this research, it was my goal to identify promising theoretical models on which to build early intervention frame- works for First Nations peoples using a four-stage method de- scribed in Mushquash et al. (2010), which emphasizes collabora- tive knowledge sharing and respect for community-based understandings. However, before applying models to guide inter- vention development, it is important to evaluate whether the pro- posed models are appropriate to use with First Nations peoples. In order to illustrate this approach, I will describe an example of how we implemented our four-stage method through the design and delivery of an alcohol use early intervention for First Nation adolescents. I will then describe how this approach may contribute to improvements in policy, practice, and research. …