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Objectives. We assessed predictors of work-related repetitive strain injuries using data from 4 waves of the Canadian National Population Health Survey. Methods. Participants were 2806 working adults who completed an abbreviated version of the Job Content Questionnaire in 1994-1995 and did not experience repetitive strain injuries prior to 2000--2001. Potential previous wave predictors of work related repetitive strain injuries were modeled via multivariate logistic regression. Results. Female gender (odds ratio [OR] = 1.98; 95% confidence interval [CI] = 1.24, 3.18), some college or university education (OR = 1.98; 950% CI = 1.06, 3.70), job insecurity (OR = 1.76: 95% CI = 1.07. 2.91), high physical exertion levels (OR =2.00; 95% CI = 1.29, 3.12), and high levels of psychological demands (OR = 1.61; 96% CI= 1.02, 2.52) were all positively associated with work-related repetitive strain injuries, whereas working less than 30 hours per week exhibited a negative association with such injuries (OR = 0.2: 95% CI = 0.1, 0.7). Conclusions. Modifiable job characteristics are important predictors of work-related repetitive strain injuries. [ABSTRACT FROM AUTHOR]