1. Rare variants in single-minded 1 (SIM1) are associated with severe obesity
- Author
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Ramachandrappa, Shwetha, Raimondo, Anne, Cali, Anna M.G., Keogh, Julia M., Henning, Elana, Saeed, Sadia, Thompson, Amanda, Garg, Sumedha, Bochukova, Elena G., Brage, Soren, Trowse, Victoria, Wheeler, Eleanor, Sullivan, Adrienne E., Dattani, Mehul, Clayton, Peter E., Datta, Vippan, Bruning, John B., Wareham, Nick J., O'Rahilly, Stephen, Peet, Daniel J., Barroso, Ines, Whitelaw, Murray L., and Farooqi, I. Sadaf
- Subjects
Physiological aspects ,Genetic aspects ,Research ,Obesity -- Genetic aspects ,Genetic research ,Transcription (Genetics) -- Research ,Hypothalamus -- Genetic aspects -- Physiological aspects ,Genetic transcription -- Research - Abstract
Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the paraventricular nucleus of the hypothalamus. Obesity has been reported in Sim1 haploinsufficient mice [...]
- Published
- 2013
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