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Start Over Author "Li, Dang" Publisher american society for clinical investigation
2 results on '"Li, Dang"'

1. CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice

Author

Shui-bing Liu, Ming-gao Zhao, Ting Sun, Xin-shang Wang, Yu-Jiao Li, Shao-yu Guan, Qi Yang, Kun Zhang, An Liu, Yan Zhang, Le Yang, Yan-yan Guo, Yu-Mei Wu, Yan-Jiao Li, and Rui-li Dang

Subjects
0301 basic medicine, Agonist, medicine.medical_specialty, Cannabinoid receptor, medicine.drug_class, Hormone Replacement Therapy, medicine.medical_treatment, Ovariectomy, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Receptor, Cannabinoid, CB1, Internal medicine, medicine, Animals, Humans, Aged, Window of opportunity, Estradiol, business.industry, General Medicine, Extinction (psychology), Middle Aged, Up-Regulation, Postmenopause, MicroRNAs, 030104 developmental biology, Endocrinology, Estrogen, 030220 oncology & carcinogenesis, Ovariectomized rat, Female, Hormone therapy, business, Research Article
Abstract

Hormone therapy (HT) is reported to be deficient in improving learning and memory in older postmenopausal women according to recent clinical studies; however, the reason for failure is unknown. A “window of opportunity” for estrogen treatment is proposed to explain this deficiency. Here, we found that facilitation of memory extinction and long-term depression by 17β-estradiol (E2) was normal in mice 1 week after ovariectomy (OVX(ST)), but it was impaired in mice 3 months after ovariectomy (OVX(LT)). High-throughput sequencing revealed a decrease of miR-221-5p, which promoted cannabinoid receptor 1 (CB1) ubiquitination by upregulation of Neurl1a/b in E2-treated OVX(LT) mice. Blood samples from postmenopausal women aged 56–65 indicated decreases of miR-221-5p and 2-arachidonoylglycerol compared with samples from perimenopausal women aged 46–55. Replenishing of miR-221-5p or treatment with a CB1 agonist rescued the impairment of fear extinction in E2-treated OVX(LT) mice. The present study demonstrates that an HT time window in mice can be prolonged by cotreatment with a CB1 agonist, implying a potential strategy for HT in long-term menopausal women.

Published
2019

2. CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice.

Author

Kun Zhang, Qi Yang, Le Yang, Yan-jiao Li, Xin-shang Wang, Yu-jiao Li, Rui-li Dang, Shao-yu Guan, Yan-yan Guo, Ting Sun, Yu-mei Wu, An Liu, Yan Zhang, Shui-bing Liu, Ming-gao Zhao, Zhang, Kun, Yang, Qi, Yang, Le, Li, Yan-Jiao, and Wang, Xin-Shang

Subjects
*CANNABINOID receptors, *MICE, *HORMONE therapy, *LONG-term memory, *FEAR, *SEXUAL desire disorders, *RNA metabolism, *THERAPEUTICS, *BIOCHEMISTRY, *RESEARCH, *HORMONES, *ESTRADIOL, *ANIMAL experimentation, *RESEARCH methodology, *CELL receptors, *RNA, *EVALUATION research, *MEDICAL cooperation, *PHENOMENOLOGY, *COMPARATIVE studies, *OVARIECTOMY, *POSTMENOPAUSE
Abstract

Hormone therapy (HT) is reported to be deficient in improving learning and memory in older postmenopausal women according to recent clinical studies; however, the reason for failure is unknown. A "window of opportunity" for estrogen treatment is proposed to explain this deficiency. Here, we found that facilitation of memory extinction and long-term depression by 17β-estradiol (E2) was normal in mice 1 week after ovariectomy (OVXST), but it was impaired in mice 3 months after ovariectomy (OVXLT). High-throughput sequencing revealed a decrease of miR-221-5p, which promoted cannabinoid receptor 1 (CB1) ubiquitination by upregulation of Neurl1a/b in E2-treated OVXLT mice. Blood samples from postmenopausal women aged 56-65 indicated decreases of miR-221-5p and 2-arachidonoylglycerol compared with samples from perimenopausal women aged 46-55. Replenishing of miR-221-5p or treatment with a CB1 agonist rescued the impairment of fear extinction in E2-treated OVXLT mice. The present study demonstrates that an HT time window in mice can be prolonged by cotreatment with a CB1 agonist, implying a potential strategy for HT in long-term menopausal women. [ABSTRACT FROM AUTHOR]

Published
2019
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