1. Resistance of Ribosomal Protein mRNA Translation to Protein Synthesis Shutoff Induced by Poliovirus
- Author
-
Alessandra De Dominicis, Beatrice Cardinali, Paola Pierandrei-Amaldi, Lucia Fiore, and Nadia Campioni
- Subjects
Ribosomal Proteins ,Ribosomal Protein S6 ,Eukaryotic Large Ribosomal Subunit ,Ribosomal Protein S6 Kinases ,Immunology ,Autophagy-related protein 13 ,Biology ,Microbiology ,Molecular biology ,Virus-Cell Interactions ,Ribosomal binding site ,Poliovirus ,EIF4EBP1 ,5S ribosomal RNA ,Ribosomal protein ,Protein Biosynthesis ,Virology ,Insect Science ,Ribosomal protein s6 ,Tumor Cells, Cultured ,Humans ,Eukaryotic Small Ribosomal Subunit ,RNA, Messenger ,Phosphorylation - Abstract
Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70 s6k activity and phosphorylation of ribosomal protein S6.
- Published
- 1999