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Start Over Author "Cardinali B" Publisher american society for microbiology
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2. Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus.

Author

Cardinali B, Fiore L, Campioni N, De Dominicis A, and Pierandrei-Amaldi P

Subjects
Humans, Phosphorylation, Ribosomal Protein S6, Ribosomal Protein S6 Kinases metabolism, Ribosomal Proteins biosynthesis, Ribosomal Proteins metabolism, Tumor Cells, Cultured, Poliovirus physiology, Protein Biosynthesis, RNA, Messenger, Ribosomal Proteins genetics
Abstract

Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70(s6k) activity and phosphorylation of ribosomal protein S6.

Published
1999
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