1. Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes.
- Author
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Koch C, Jersch J, Schneck E, Edinger F, Maxeiner H, Uhle F, Weigand MA, Markmann M, Sander M, and Henrich M
- Subjects
- Animals, Caffeine pharmacology, Calcium Signaling drug effects, Humans, Rats, Calcium metabolism, Caspofungin adverse effects, Myocytes, Cardiac drug effects, Myocytes, Cardiac metabolism, Ryanodine Receptor Calcium Release Channel metabolism
- Abstract
Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca
2+ concentration ([Ca2+ ]i ) after CAS treatment. Ca2+ ions were found to be released from intracellular caffeine-sensitive stores, most probably via the activation of ryanodine receptors., (Copyright © 2018 American Society for Microbiology.)- Published
- 2018
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