1. Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis.
- Author
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De Paoli P, Basaglia G, Gennari D, Crovatto M, Modolo ML, and Santini G
- Subjects
- Acute Disease, Adult, Animals, Antigens, Protozoan, Female, Humans, In Vitro Techniques, Lymphocyte Activation, Male, Phenotype, Toxoplasma immunology, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocyte Subsets immunology, Toxoplasmosis immunology
- Abstract
Gamma and delta (gamma delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.
- Published
- 1992
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