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Your search keyword '"Forbes B"' showing total 23 results
Start Over Author "Forbes B" Publisher american society for microbiology
23 results on '"Forbes B"'

2. U.S.-Based National Sentinel Surveillance Study for the Epidemiology of Clostridium difficile-Associated Diarrheal Isolates and Their Susceptibility to Fidaxomicin

Author

Snydman, D. R., primary, McDermott, L. A., additional, Jacobus, N. V., additional, Thorpe, C., additional, Stone, S., additional, Jenkins, S. G., additional, Goldstein, E. J. C., additional, Patel, R., additional, Forbes, B. A., additional, Mirrett, S., additional, Johnson, S., additional, and Gerding, D. N., additional

Published
2015
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22. Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection

Author

Nigel P. Minton, Robin C. Spiller, Emma C. Stevenson, Sarah A. Kuehne, Giles Major, and Forbes, B. A.

Subjects
Male, 0301 basic medicine, Microbiology (medical), 030106 microbiology, Drug resistance, Biology, Ribotyping, Feces, 03 medical and health sciences, chemistry.chemical_compound, Recurrence, Drug Resistance, Bacterial, medicine, Humans, Aged, 80 and over, Clostridioides difficile, Coinfection, Bacteriology, Sequence Analysis, DNA, Pseudomembranous colitis, Clostridium difficile, medicine.disease, Rifamycins, Virology, Anti-Bacterial Agents, Bacterial Typing Techniques, Rifaximin, Diarrhea, chemistry, Clostridium Infections, medicine.symptom, Rifampicin, medicine.drug
Abstract

Clostridium difficile ( Peptoclostridium difficile ) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Around 20% of patients may suffer recurrent disease, which often requires rehospitalization of patients. C. difficile was isolated from stool samples from a patient with two recurrent C. difficile infections. PCR ribotyping, whole-genome sequencing, and phenotypic assays were used to characterize these isolates. Genotypic and phenotypic screening of C. difficile isolates revealed multiple PCR ribotypes present and the emergence of rifamycin resistance during the infection cycle. Understanding both the clinical and bacterial factors that contribute to the course of recurrent infection could inform strategies to reduce recurrence. (This study has been registered at ClinicalTrials.gov under registration no. NCT01670149.)

Published
2016
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23. Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers.

Author

Stressmann FA, Rogers GB, Klem ER, Lilley AK, Donaldson SH, Daniels TW, Carroll MP, Patel N, Forbes B, Boucher RC, Wolfgang MC, and Bruce KD

Subjects
Adolescent, Adult, Bacteria genetics, Cluster Analysis, DNA, Bacterial chemistry, DNA, Bacterial genetics, DNA, Ribosomal chemistry, DNA, Ribosomal genetics, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Polymorphism, Restriction Fragment Length, RNA, Ribosomal, 16S genetics, Sequence Analysis, DNA, United Kingdom, United States, Young Adult, Bacteria classification, Bacteria isolation & purification, Biodiversity, Cystic Fibrosis microbiology, Lung microbiology
Abstract

The aim of this study was to determine whether geographical differences impact the composition of bacterial communities present in the airways of cystic fibrosis (CF) patients attending CF centers in the United States or United Kingdom. Thirty-eight patients were matched on the basis of clinical parameters into 19 pairs comprised of one U.S. and one United Kingdom patient. Analysis was performed to determine what, if any, bacterial correlates could be identified. Two culture-independent strategies were used: terminal restriction fragment length polymorphism (T-RFLP) profiling and 16S rRNA clone sequencing. Overall, 73 different terminal restriction fragment lengths were detected, ranging from 2 to 10 for U.S. and 2 to 15 for United Kingdom patients. The statistical analysis of T-RFLP data indicated that patient pairing was successful and revealed substantial transatlantic similarities in the bacterial communities. A small number of bands was present in the vast majority of patients in both locations, indicating that these are species common to the CF lung. Clone sequence analysis also revealed that a number of species not traditionally associated with the CF lung were present in both sample groups. The species number per sample was similar, but differences in species presence were observed between sample groups. Cluster analysis revealed geographical differences in bacterial presence and relative species abundance. Overall, the U.S. samples showed tighter clustering with each other compared to that of United Kingdom samples, which may reflect the lower diversity detected in the U.S. sample group. The impact of cross-infection and biogeography is considered, and the implications for treating CF lung infections also are discussed.

Published
2011
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