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Your search keyword '"Groenendijk, Martijn"' showing total 2 results
Start Over Author "Groenendijk, Martijn" Publisher american society for microbiology
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2. Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans.

Author

de Fost M, Hartskeerl RA, Groenendijk MR, and van der Poll T

Subjects
Humans, Immunity, Cellular immunology, In Vitro Techniques, Male, Tumor Necrosis Factor-alpha metabolism, Interferon-gamma metabolism, Interleukin-12 metabolism, Leptospira interrogans immunology, Leptospirosis immunology
Abstract

Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-gamma) and the IFN-gamma-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-gamma was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

Published
2003
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