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Your search keyword '"Gruenheid, Samantha"' showing total 12 results
Start Over Author "Gruenheid, Samantha" Publisher american society for microbiology
12 results on '"Gruenheid, Samantha"'

2. Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of Salmonella Virulence

Author

Crouse, Alanna, primary, Schramm, Catherine, additional, Emond-Rheault, Jean-Guillaume, additional, Herod, Adrian, additional, Kerhoas, Maud, additional, Rohde, John, additional, Gruenheid, Samantha, additional, Kukavica-Ibrulj, Irena, additional, Boyle, Brian, additional, Greenwood, Celia M. T., additional, Goodridge, Lawrence D., additional, Garduno, Rafael, additional, Levesque, Roger C., additional, Malo, Danielle, additional, and Daigle, France, additional

Published
2020
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4. Molecular analysis as an aid to assess the public health risk of non-O157 shiga toxin-producing Escherichia coli strains

Author

Coombes, Brian K., Wickham, Mark E., Mascarenhas, Mariola, Gruenheid, Samantha, and Karmali, Mohamed A.

Subjects
Escherichia coli -- Physiological aspects, Escherichia coli -- Genetic aspects, Polymerase chain reaction -- Analysis, Disease transmission -- Research, Bacterial toxins -- Health aspects, Biological sciences
Abstract

The identification of three genomic islands encoding non-LEE effector (nle) genes and 14 individual nle genes in non-O157 shiga toxin-producing Escherichia coli (STEC) strains is reported. A molecular risk assessment method to rapidly recognize and respond to non-O157 STEC strains is presented.

Published
2008

12. Molecular Analysis as an Aid To Assess the Public Health Risk of Non-O 157 Shiga Toxin-Producing Escherichia coli Strains.

Author

Coombes, Brian K., Wickham, Mark E., Mascarenhas, Mariola, Gruenheid, Samantha, Finlay, B. Brett, and Karmali, Mohamed A.

Subjects
*VEROCYTOTOXINS, *ESCHERICHIA coli, *HEALTH risk assessment, *ENTEROTOXINS, *BACTERIAL toxins, *BACTERIAL antigens
Abstract

Shiga toxin-producing Escherichia coli (STEC) strains are commensal bacteria in cattle with high potential for environmental and zoonotic transmission to humans. Although O157:H7 is the most common STEC serotype, there is growing concern over the emergence of more than 200 highly virulent non-O157 STEC serotypes that are globally distributed, several of which are associated with outbreaks and/or severe human illness such as hemolytic-uremic syndrome (HUS) and hemorrhagic colitis. At present, the underlying genetic basis of virulence potential in non-O157 STEC is unknown, although horizontal gene transfer and the acquisition of new pathogenicity islands are an expected origin. We used seropathotype classification as a framework to identity genetic elements that distinguish non-O157 STEC strains posing a serious risk to humans from STEC strains that are not associated with severe and epidemic disease. We report the identification of three genomic islands encoding non-LEE effector (nle) genes and 14 individual nle genes in non-O157 STEC strains that correlate independently with outbreak and HUS potential in humans. The implications for transmissible zoonotic spread and public health are discussed. These results and methods offer a molecular risk assessment strategy to rapidly recognize and respond to non-O157 STEC strains from environmental and animal sources that might pose serious public health risks to humans. [ABSTRACT FROM AUTHOR]

Published
2008
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