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Start Over Author "Kakkola, Laura" Publisher american society for microbiology
14 results on '"Kakkola, Laura"'

1. Serological Follow-Up Study Indicates High Seasonal Coronavirus Infection and Reinfection Rates in Early Childhood

Author

Kolehmainen, Pekka, primary, Heroum, Jemna, additional, Jalkanen, Pinja, additional, Huttunen, Moona, additional, Toivonen, Laura, additional, Marjomäki, Varpu, additional, Waris, Matti, additional, Smura, Teemu, additional, Kakkola, Laura, additional, Tauriainen, Sisko, additional, Peltola, Ville, additional, and Julkunen, Ilkka, additional

Published
2022
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2. Vaccine-Induced Antibody Responses against SARS-CoV-2 Variants-Of-Concern Six Months after the BNT162b2 COVID-19 mRNA Vaccination

Author

Jalkanen, Pinja, primary, Kolehmainen, Pekka, additional, Haveri, Anu, additional, Huttunen, Moona, additional, Laine, Larissa, additional, Österlund, Pamela, additional, Tähtinen, Paula A., additional, Ivaska, Lauri, additional, Maljanen, Sari, additional, Reinholm, Arttu, additional, Belik, Milja, additional, Smura, Teemu, additional, Häkkinen, Hanni K., additional, Ortamo, Eeva, additional, Kantele, Anu, additional, Julkunen, Ilkka, additional, Lempainen, Johanna, additional, and Kakkola, Laura, additional

Published
2022
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3. Serological Follow-Up Study Indicates High Seasonal Coronavirus Infection and Reinfection Rates in Early Childhood

Author

Kolehmainen, Pekka, Heroum, Jemna, Jalkanen, Pinja, Huttunen, Moona, Toivonen, Laura, Marjomäki, Varpu, Waris, Matti, Smura, Teemu, Kakkola, Laura, Tauriainen, Sisko, Peltola, Ville, Julkunen, Ilkka, Department of Virology, HUSLAB, and University of Helsinki

Subjects
11832 Microbiology and virology, viruses, vasta-aineet, virus diseases, serology, seasonal coronavirus, lapset (ikäryhmät), epidemiat, SARS-COV-2, OC43, enzyme immunoassay, koronavirukset, NL63, stomatognathic system, children, 3123 Gynaecology and paediatrics, respiratory infection, tartuntataudit, antibodies, hengityselinten taudit, serologia, HKU1, 229E, NUCLEOCAPSID PROTEIN
Abstract

Seasonal human coronaviruses (HCoVs) cause respiratory infections, especially in children. Currently, the knowledge on early childhood seasonal coronavirus infections and the duration of antibody levels following the first infections is limited. Here we analyzed serological follow-up samples to estimate the rate of primary infection and reinfection(s) caused by seasonal coronaviruses in early childhood. Serum specimens were collected from 140 children at ages of 13, 24, and 36 months (1, 2, and 3 years), and IgG antibody levels against recombinant HCoV nucleoproteins (N) were measured by enzyme immunoassay (EIA). Altogether, 84% (118/140) of the children were seropositive for at least one seasonal coronavirus N by the age of 3 years. Cumulative seroprevalences for HCoVs 229E, HKU1, NL63, and OC43 increased by age, and they were 45%, 27%, 70%, and 44%, respectively, at the age of 3 years. Increased antibody levels between yearly samples indicated reinfections by 229E, NL63, and OC43 viruses in 20-48% of previously seropositive children by the age of 3 years. Antibody levels declined 54-73% or 31-77% during the year after seropositivity in children initially seropositive at 1 or 2 years of age, respectively, in case there was no reinfection. The correlation of 229E and NL63, and OC43 and HKU1 EIA results, suggested potential cross-reactivity between the N specific antibodies inside the coronavirus genera. The data shows that seasonal coronavirus infections and reinfections are common in early childhood and the antibody levels decline relatively rapidly. IMPORTANCE The rapid spread of COVID-19 requires better knowledge on the rate of coronavirus infections and coronavirus specific antibody responses in different population groups. In this work we analyzed changes in seasonal human coronavirus specific antibodies in young children participating in a prospective 3-year serological follow-up study. We show that based on seropositivity and changes in serum coronavirus antibody levels, coronavirus infections and reinfections are common in early childhood and the antibodies elicited by the infection decline relatively rapidly. These observations provide further information on the characteristics of humoral immune responses of coronavirus infections in children. The rapid spread of COVID-19 requires better knowledge on the rate of coronavirus infections and coronavirus specific antibody responses in different population groups. In this work we analyzed changes in seasonal human coronavirus specific antibodies in young children participating in a prospective 3-year serological follow-up study.

Published
2022

4. A Highly Sensitive and Specific SARS-CoV-2 Spike- and Nucleoprotein-Based Fluorescent Multiplex Immunoassay (FMIA) to Measure IgG, IgA, and IgM Class Antibodies

Author

Solastie, Anna, primary, Virta, Camilla, additional, Haveri, Anu, additional, Ekström, Nina, additional, Kantele, Anu, additional, Miettinen, Simo, additional, Lempainen, Johanna, additional, Jalkanen, Pinja, additional, Kakkola, Laura, additional, Dub, Timothée, additional, Julkunen, Ilkka, additional, and Melin, Merit, additional

Published
2021
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7. Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014

Author

Mishel, Polina, primary, Ojala, Teija, additional, Benner, Christian, additional, Lakspere, Triin, additional, Bychkov, Dmitrii, additional, Jalovaara, Petri, additional, Kakkola, Laura, additional, Kallio-Kokko, Hannimari, additional, Kantele, Anu, additional, Kankainen, Matti, additional, Ikonen, Niina, additional, Ripatti, Samuli, additional, Julkunen, Ilkka, additional, and Kainov, Denis E., additional

Published
2015
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8. Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland

Author

Jalovaara, Petri, primary, Mishel, Polina, additional, Kallio-Kokko, Hannimari, additional, Valkonen, Miia, additional, Kantele, Anu, additional, Ikonen, Niina, additional, Julkunen, Ilkka, additional, Kakkola, Laura, additional, Kutsaya, Anna, additional, Vuorinen, Tytti, additional, Mattila, Pirkko, additional, Almusa, Henrikki, additional, and Kainov, Denis, additional

Published
2015
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10. Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013

Author

Lakspere, Triin, primary, Tynell, Janne, additional, Kaloinen, Minttu, additional, Vanlede, Maarten, additional, Parsons, Alun, additional, Ikonen, Niina, additional, Kallio-Kokko, Hannimari, additional, Kantele, Anu, additional, Mattila, Pirkko, additional, Almusa, Henrikki, additional, Julkunen, Ilkka, additional, Kainov, Denis, additional, and Kakkola, Laura, additional

Published
2014
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14. Human Circovirus TT Virus Genotype 6 Expresses Six Proteins following Transfection of a Full-Length Clone.

Author

Jianming Qiu, Kakkola, Laura, Fang Cheng, Chaoyang Ye, Söderlund-Venermo, Maria, Hedman, Klaus, and Pintel, David J.

Subjects
*VIRUS diseases, *GENETIC transformation, *GENETIC polymorphisms, *GREEN fluorescent protein, *HEMAGGLUTININ, *GENOMES
Abstract

The expression profile of the circovirus TTV has not yet been fully characterized. In this paper, we show that following transfection of a full-length viral clone of TTV genotype 6, each of the three virally encoded mRNAs is translated from two initiating AUGs, and therefore, the TTV genome generates at least six proteins. Localization studies of hemagglutinin-tagged versions of these proteins in fixed cells, and green fluorescent protein-tagged versions of these proteins in living cells, expressed following transfection, demonstrated that two were primarily nuclear, two were primarily cytoplasmic, and two were found throughout the cell. [ABSTRACT FROM AUTHOR]

Published
2005
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