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Your search keyword '"Karunajeewa, Harin"' showing total 17 results
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17 results on '"Karunajeewa, Harin"'

1. Piperaquine Pharmacokinetic and Pharmacodynamic Profiles in Healthy Volunteers of Papua New Guinea after Administration of Three-Monthly Doses of Dihydroartemisinin–Piperaquine

Author

Millat-Martínez, Pere, primary, Salman, Sam, additional, Moore, Brioni R., additional, Baro, Bàrbara, additional, Page-Sharp, Madhu, additional, Batty, Kevin T., additional, Robinson, Leanne J., additional, Pomat, William, additional, Karunajeewa, Harin, additional, Laman, Moses, additional, Manning, Laurens, additional, Mitjà, Oriol, additional, and Bassat, Quique, additional

Published
2022
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2. Electrocardiographic Safety of Repeated Monthly Dihydroartemisinin-Piperaquine as a Candidate for Mass Drug Administration

Author

Millat-Martínez, Pere, primary, Ila, Rhoda, additional, Laman, Moses, additional, Robinson, Leanne, additional, Karunajeewa, Harin, additional, Abel, Haina, additional, Pulai, Kevin, additional, Sanz, Sergi, additional, Manning, Laurens, additional, Moore, Brioni, additional, Bassat, Quique, additional, and Mitjà, Oriol, additional

Published
2018
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3. Optimal Antimalarial Dose Regimens for Sulfadoxine-Pyrimethamine with or without Azithromycin in Pregnancy Based on Population Pharmacokinetic Modeling

Author

Salman, Sam, primary, Baiwog, Francisca, additional, Page-Sharp, Madhu, additional, Griffin, Susan, additional, Karunajeewa, Harin A., additional, Mueller, Ivo, additional, Rogerson, Stephen J., additional, Siba, Peter M., additional, Ilett, Kenneth F., additional, and Davis, Timothy M. E., additional

Published
2017
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4. Plasmodium falciparum and Plasmodium vivax Genotypes and Efficacy of Intermittent Preventive Treatment in Papua New Guinea

Author

Barnadas, Celine, primary, Senn, Nicolas, additional, Iga, Jonah, additional, Timinao, Lincoln, additional, Javati, Sarah, additional, Malau, Elisheba, additional, Rarau, Patricia, additional, Reeder, John C., additional, Siba, Peter, additional, Karunajeewa, Harin, additional, Zimmerman, Peter A., additional, Davis, Timothy M., additional, and Mueller, Ivo, additional

Published
2014
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9. Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy

Author

Karunajeewa, Harin A., primary, Salman, Sam, additional, Mueller, Ivo, additional, Baiwog, Francisca, additional, Gomorrai, Servina, additional, Law, Irwin, additional, Page-Sharp, Madhu, additional, Rogerson, Stephen, additional, Siba, Peter, additional, Ilett, Kenneth F., additional, and Davis, Timothy M. E., additional

Published
2010
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10. Pharmacokinetic Properties of Azithromycin in Pregnancy

Author

Salman, Sam, primary, Rogerson, Stephen J., additional, Kose, Kay, additional, Griffin, Susan, additional, Gomorai, Servina, additional, Baiwog, Francesca, additional, Winmai, Josephine, additional, Kandai, Josin, additional, Karunajeewa, Harin A., additional, O'Halloran, Sean J., additional, Siba, Peter, additional, Ilett, Kenneth F., additional, Mueller, Ivo, additional, and Davis, Timothy M. E., additional

Published
2010
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11. Pharmacokinetic Properties of Sulfadoxine-Pyrimethamine in Pregnant Women

Author

Karunajeewa, Harin A., primary, Salman, Sam, additional, Mueller, Ivo, additional, Baiwog, Francisca, additional, Gomorrai, Servina, additional, Law, Irwin, additional, Page-Sharp, Madhu, additional, Rogerson, Stephen, additional, Siba, Peter, additional, Ilett, Kenneth F., additional, and Davis, Timothy M. E., additional

Published
2009
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17. Molecular assessment of Plasmodium falciparum resistance to antimalarial drugs in Papua New Guinea using an extended ligase detection reaction fluorescent microsphere assay.

Author

Wong RP, Karunajeewa H, Mueller I, Siba P, Zimmerman PA, and Davis TM

Subjects
Animals, Child, Preschool, Fluorescence, Humans, Infant, Ligases metabolism, Malaria, Falciparum parasitology, Microspheres, Multidrug Resistance-Associated Proteins genetics, Papua New Guinea, Parasitic Sensitivity Tests, Plasmodium falciparum genetics, Plasmodium falciparum isolation & purification, Antimalarials pharmacology, Drug Resistance genetics, Plasmodium falciparum drug effects, Polymorphism, Single Nucleotide genetics, Protozoan Proteins genetics
Abstract

Surveillance for Plasmodium falciparum drug resistance mutations is becoming an established tool for assessing antimalarial treatment effectiveness. We used an extended version of a high-throughput post-PCR multiplexed ligase detection reaction fluorescent microsphere assay (LDR-FMA) to detect single-nucleotide P. falciparum drug resistance polymorphisms in 402 isolates from children in Papua New Guinea (PNG) participating in an antimalarial treatment trial. There was a fixation of P. falciparum crt (pfcrt) K76T, pfdhfr C59R and S108N, and pfmdr1 mutations (92%, 93%, 95%, and 91%, respectively). Multiple mutations were frequent. Eighty-eight percent of isolates possessed a quintuple mutation (underlined), SVMNT, NRNI, KAA, and YYSND, in codons 72 to 76 for pfcrt; 51, 59, 108, and 164 for pfdhfr; 540, 581, and 613 for pfdhps; and 86, 184, 1034, 1042, and 1246 for pfmdr1, and four of these carried the K540E pfdhps allele. The pfmdr1 D1246Y mutation was associated with PCR-corrected day 42 in vivo treatment failure in children allocated piperaquine-dihydroartemisinin (P = 0.004). Although the pfmdr1 NFSDD haplotype was found in only four isolates, it has been associated with artemether-lumefantrine treatment failure in Africa. LDR-FMA allows the large-scale assessment of resistance-associated single-nucleotide polymorphisms (SNPs). Our findings reflect previous heavy 4-aminoquinoline/sulfadoxine-pyrimethamine use in PNG. Since artemether-lumefantrine and piperaquine-dihydroartemisinin will become first- and second-line treatments, respectively, the monitoring of pfmdr1 SNPs appears to be a high priority.

Published
2011
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