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Your search keyword '"LIU, Hai Can"' showing total 6 results
Start Over Author "LIU, Hai Can" Publisher american society for microbiology
6 results on '"LIU, Hai Can"'

1. The Evolution and Transmission Dynamics of Multidrug-Resistant Tuberculosis in an Isolated High-Plateau Population of Tibet, China

Author

Jiang, Qi, primary, Liu, Hai-Can, additional, Liu, Qing-Yun, additional, Phelan, Jody E., additional, Tao, Feng-Xi, additional, Zhao, Xiu-Qin, additional, Wang, Jian, additional, Glynn, Judith R., additional, Takiff, Howard E., additional, Clark, Taane G., additional, Wan, Kang-Lin, additional, and Gao, Qian, additional

Published
2023
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6. Mutations within embCAB Are Associated with Variable Level of Ethambutol Resistance in Mycobacterium tuberculosis Isolates from China.

Author

Sun Q, Xiao TY, Liu HC, Zhao XQ, Liu ZG, Li YN, Zeng H, Zhao LL, and Wan KL

Subjects
China, Drug Resistance, Bacterial drug effects, Drug Resistance, Bacterial genetics, Humans, Multivariate Analysis, Mutation, Operon, Tuberculosis, Pulmonary microbiology, Antitubercular Agents pharmacology, Bacterial Proteins genetics, Ethambutol pharmacology, Mycobacterium tuberculosis drug effects, Mycobacterium tuberculosis genetics
Abstract

The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embCAB among 125 Mycobacterium tuberculosis isolates from China and quantified their EMB MICs by testing growth at 10 concentrations. Furthermore, a multivariate regression model was established to assess the effects of both individual mutations and multiple mutations. Our results revealed that in China, 82.6% of EMB-resistant isolates (71/86 isolates) harbored at least one mutation within embCAB Most of the mutations were located in the embB and embA upstream region. Several individual mutations and multiple mutations within this region contributed to the different levels of EMB resistance. Their effects were statistically significant. Additionally, there was an association between high-level EMB resistance and multiple mutations., (Copyright © 2017 American Society for Microbiology.)

Published
2017
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